Jing Pengyu, Xie Nianlin, Zhu Ximing, Dang Haizhou, Gu Zhongping
Department of Thoracic Surgery, The Second Affiliated Hospital of AFMU, Air Force Medical University, Xi'an 710038, China.
J Thorac Dis. 2018 Dec;10(12):7014-7019. doi: 10.21037/jtd.2018.10.100.
Arginine methylation as a common pattern of post-translational modification is involved in many cellular biological processes. Protein arginine methyltransferase 5 (PRMT5) is a primary enzyme in charge of symmetric dimethylation (me2s) of arginine residues. Increasing literatures lead to the belief that PRMT5, as a potential oncogene, plays crucial roles in the tumorigenesis and progression of cancers. First of all, PRMT5 is overexpressed in several cancer cells, with various sub-cellular localization in different type of cells and different phases. Besides, PRMT5 participates in controlling cellular proliferation, differentiation, invasion, migration as well apoptosis through histone and other protein methylation. Moreover, PRMT5 is essential for growth and metastasis of lung cancer cells, and its overexpression indicates a poor clinical outcome of lung cancer. Therefore, in this review, we reviewed the substantial new literatures on PRMT5 and its functions, in order to highlight the significance of understanding this essential enzyme in lung cancer tumorigenesis and progression.
精氨酸甲基化作为一种常见的翻译后修饰模式，参与了许多细胞生物学过程。蛋白质精氨酸甲基转移酶5（PRMT5）是负责精氨酸残基对称二甲基化（me2s）的主要酶。越来越多的文献表明，PRMT5作为一种潜在的癌基因，在癌症的发生和发展中起着关键作用。首先，PRMT5在几种癌细胞中过表达，在不同类型的细胞和不同阶段具有不同的亚细胞定位。此外，PRMT5通过组蛋白和其他蛋白质甲基化参与控制细胞增殖、分化、侵袭、迁移以及凋亡。此外，PRMT5对肺癌细胞的生长和转移至关重要，其过表达表明肺癌的临床预后较差。因此，在本综述中，我们回顾了关于PRMT5及其功能的大量新文献，以强调了解这种关键酶在肺癌发生和发展中的重要性。
