Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen University School of Medicine, Shenzhen, China.
Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Biomed Pharmacother. 2019 Jun;114:108790. doi: 10.1016/j.biopha.2019.108790. Epub 2019 Mar 20.
Protein arginine methyltransferases (PRMTs) play important roles in protein methylation. PRMT5 is the major type II arginine methyltransferase that catalyzes the transfer of two methyl groups symmetrically to the arginine residues of either histone or non-histone proteins. In recent years, increasing evidence has shown that PRMT5, as an oncogene, plays an indispensable regulatory role in the pathological progression of several human cancers by promoting the proliferation, invasion, and migration of cancer cells. PRMT5 is overexpressed in many malignant tumors and plays an important role in the occurrence and development of cancer, which suggests that PRMT5 may become a potential biomarker or therapeutic target of cancer. This article reviews the biological function, mechanism, and clinical significance of PRMT5 in tumorigenesis.
蛋白质精氨酸甲基转移酶（PRMTs）在蛋白质甲基化中发挥重要作用。PRMT5 是主要的 II 型精氨酸甲基转移酶，可催化将两个甲基基团对称地转移到组蛋白或非组蛋白蛋白质的精氨酸残基上。近年来，越来越多的证据表明，PRMT5 作为一种癌基因，通过促进癌细胞的增殖、侵袭和迁移，在几种人类癌症的病理进展中发挥不可或缺的调节作用。PRMT5 在许多恶性肿瘤中过度表达，在癌症的发生和发展中发挥重要作用，这表明 PRMT5 可能成为癌症的潜在生物标志物或治疗靶点。本文综述了 PRMT5 在肿瘤发生中的生物学功能、机制和临床意义。
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