有和没有髌股疼痛的年轻成年女性的髌骨对线与软骨生物标志物的比较：一项初步研究。
COMPARISON OF PATELLA ALIGNMENT AND CARTILAGE BIOMARKERS IN YOUNG ADULT FEMALES WITH AND WITHOUT PATELLOFEMORAL PAIN: A PILOT STUDY.
作者信息
Bolgla Lori A, Gordon Richard, Sloan Gloria, Pretlow Lester G, Lyon Matthew, Fulzele Sadanand
机构信息
College of Allied Health Sciences, Augusta University, Augusta, GA, USA.
Department of Emergency Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
出版信息
Int J Sports Phys Ther. 2019 Feb;14(1):46-54.
BACKGROUND
Limited data exist regarding an absolute association between PFP and PFJOA. Understanding this relationship will support the need for early interventions to manage PFP.
HYPOTHESIS/PURPOSE: This study was conducted to determine if females with PFP have a patella position and cartilage biomarkers similar to individuals with PFJOA. It was hypothesized that females with PFP and excessive patella lateralization would have higher cartilage biomarker levels than controls. It also was hypothesized that a significant association would exist between pain and cartilage biomarker levels in subjects with excessive patella lateralization.
STUDY DESIGN
Single-occasion, cross-sectional, observational.
METHODS
Pain was assessed using a 10-cm visual analog scale (VAS) for activity pain over the previous week. Patella offset position (RAB angle) was measured using diagnostic ultrasound. Urine was collected and cartilage biomarkers quantified by analyzing C-telopeptide fragments of type II collagen (uCTX-II). Independent -tests were used to determine between-group differences for RAB angle and uCTX-II. Bivariate correlations were used to determine associations between VAS and uCTX-II for females with PFP.
RESULTS
Subjects (age range 20 to 30 years) had similar RAB angles ( = 0.21) and uCTX-II ( = 0.91). A significant association only existed between VAS scores and uCTX-II for females with PFP who had a RAB angle > 13 ° ( = 0.86; = 0.003). Comparison of uCTX-II in the 25-to-30-year-old females with PFP and excessive patella lateralization in the current study to published normative data showed that this cohort had elevated biomarkers.
CONCLUSION
These findings support that a certain cohort of individuals with PFP have features similar to individuals with confirmed PFJOA (patella lateralization and elevated biomarkers). Additional studies are needed to determine if interventions can reverse not only pain but biomarker levels.
LEVEL OF EVIDENCE
2b (diagnosis).
背景
关于髌股疼痛（PFP）与髌股关节骨关节炎（PFJOA）之间的绝对关联，现有数据有限。了解这种关系将有助于支持早期干预以管理PFP的必要性。
假设/目的：本研究旨在确定患有PFP的女性的髌骨位置和软骨生物标志物是否与患有PFJOA的个体相似。研究假设患有PFP且髌骨过度外移的女性的软骨生物标志物水平高于对照组。还假设在髌骨过度外移的受试者中，疼痛与软骨生物标志物水平之间存在显著关联。
研究设计
单次、横断面、观察性研究。
方法
使用10厘米视觉模拟量表（VAS）评估前一周的活动疼痛。使用诊断超声测量髌骨偏移位置（RAB角）。收集尿液并通过分析II型胶原的C-末端肽片段（uCTX-II）对软骨生物标志物进行定量。采用独立样本t检验确定RAB角和uCTX-II的组间差异。采用双变量相关性分析确定患有PFP的女性的VAS与uCTX-II之间的关联。
结果
受试者（年龄范围20至30岁）的RAB角（P = 0.21）和uCTX-II（P = 0.91）相似。仅在RAB角>13°的患有PFP的女性中，VAS评分与uCTX-II之间存在显著关联（P = 0.86；P = 0.003）。将本研究中25至30岁患有PFP且髌骨过度外移的女性的uCTX-II与已发表的正常数据进行比较，结果显示该队列的生物标志物水平升高。
结论
这些发现支持，特定队列的PFP个体具有与确诊的PFJOA个体相似的特征（髌骨外移和生物标志物水平升高）。需要进一步的研究来确定干预措施是否不仅可以缓解疼痛，还能逆转生物标志物水平。
证据水平
2b（诊断）。
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