La Trobe Sports and Exercise Medicine Research Centre, School of Allied Health, La Trobe University, Bundoora, Victoria, Australia.
Deparment of Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University, Boston, Massachusetts, USA.
Br J Sports Med. 2017 Aug;51(16):1195-1208. doi: 10.1136/bjsports-2017-097515. Epub 2017 Apr 29.
Patellofemoral osteoarthritis (PF OA) is more prevalent than previously thought and contributes to patient's suffering from knee OA. Synthesis of prevalence data can provide estimates of the burden of PF OA.
This study aims to conduct a systematic review and meta-analysis on the prevalence of PF OA and structural damage based on radiography and MRI studies in different populations.
We searched six electronic databases and reference lists of relevant cross-sectional and observational studies reporting the prevalence of PF OA. Two independent reviewers appraised methodological quality. Where possible, data were pooled using the following categories: radiography and MRI studies.
Eighty-five studies that reported the prevalence of patellofemoral OA and structural damage were included in this systematic review. Meta-analysis revealed a high prevalence of radiographic PF OA in knee pain or symptomatic knee OA (43%), radiographic knee OA or at risk of developing OA (48%) and radiographic and symptomatic knee OA (57%) cohorts. The MRI-defined structural PF damage in knee pain or symptomatic population was 32% and 52% based on bone marrow lesion and cartilage defect, respectively.
One half of people with knee pain or radiographic OA have patellofemoral involvement. Prevalence of MRI findings was high in symptomatic and asymptomatic population. These pooled data and the variability found can provide evidence for future research addressing risk factors and treatments for PF OA.
PROSPERO systematic review protocol (CRD42016035649).
髌股关节骨关节炎（PF OA）比以前认为的更为普遍，导致膝关节 OA 患者遭受痛苦。对流行率数据的综合分析可以估计 PF OA 的负担。
本研究旨在对基于影像学和 MRI 研究的不同人群中 PF OA 和结构损伤的流行率进行系统评价和荟萃分析。
我们检索了六个电子数据库和相关横断面和观察性研究的参考文献列表，这些研究报告了 PF OA 的流行率。两名独立的审查员评估了方法学质量。在可能的情况下，使用以下类别汇总数据：影像学和 MRI 研究。
共有 85 项研究报告了髌股关节炎和结构损伤的流行率，纳入了本系统评价。荟萃分析显示，在膝关节疼痛或有症状的膝关节 OA（43%）、有影像学膝关节 OA 或有发生 OA 风险（48%）和有影像学和有症状的膝关节 OA（57%）队列中，放射影像学 PF OA 的患病率较高。在膝关节疼痛或有症状人群中，基于骨髓病变和软骨缺损，MRI 定义的结构性 PF 损伤分别为 32%和 52%。
一半有膝关节疼痛或放射影像学 OA 的人有髌股关节受累。在有症状和无症状人群中，MRI 发现的患病率较高。这些汇总数据及其发现的变异性可以为未来研究 PF OA 的危险因素和治疗方法提供证据。
PROSPERO 系统评价方案（CRD42016035649）。
