含庆大霉素、阿莫西林和甲硝唑的糊剂在乳牙牙髓病治疗中的体内评估
Evaluation of Paste Containing Gentamicin, Amoxicillin and Metronidazole in Endodontic Treatment of Primary Molars in Vivo.
作者信息
Parakh Keyura, Shetty Raghavendra Manjunath
出版信息
Chin J Dent Res. 2019;22(1):57-64. doi: 10.3290/j.cjdr.a41776.
OBJECTIVE
To evaluate and compare the efficacy of gentamicin, amoxicillin and metronidazole (GAM) antibiotic paste in noninstrumentation and instrumentation techniques in infected primary molars.
METHODS
Sixty primary molars in children of 4 to 8 years were selected and divided into four groups: teeth without any periapical or furcation involvement undergoing pulpectomy by noninstrumentation (Group N1) and instrumentation (Group N2) technique using GAM antibiotic paste; teeth with periapical or furcation involvement undergoing pulpectomy by noninstrumentation (Group R1) and instrumentation (Group R2) technique using GAM antibiotic paste. Regular follow-up at 3, 6 and 12 months was carried out for each group and all the clinical and radiographic changes were evaluated statistically using SPSS software. The level of significance was set to P < 0.05.
RESULTS
Overall, 73.3% of success was observed in Group N1, 71.4% in Group N2, 86.7% in both Group R1 and Group R2 (P = 0.003).
CONCLUSION
The GAM lesion sterilisation and tissue repair (GAM-LSTR) technique can be an alternative to conventional pulpectomy.
目的
评估和比较庆大霉素、阿莫西林和甲硝唑（GAM）抗生素糊剂在非器械法和器械法治疗感染乳磨牙中的疗效。
方法
选取60颗4至8岁儿童的乳磨牙，分为四组：无根尖或根分叉病变的牙齿，采用非器械法（N1组）和器械法（N2组）使用GAM抗生素糊剂进行牙髓摘除术；有根尖或根分叉病变的牙齿，采用非器械法（R1组）和器械法（R2组）使用GAM抗生素糊剂进行牙髓摘除术。对每组进行3、6和12个月的定期随访，并使用SPSS软件对所有临床和影像学变化进行统计学评估。显著性水平设定为P < 0.05。
结果
总体而言，N1组成功率为73.3%，N2组为71.4%，R1组和R2组均为86.7%（P = 0.003）。
结论
GAM病变消毒和组织修复（GAM-LSTR）技术可作为传统牙髓摘除术的替代方法。
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