Shankar Karthika, Ramkumar Hemalatha, Dhakshinamoorthy Senthil, Paulindraraj Shankar, Jayakaran Trophimus G, Bommareddy Charishma S
Department of Pediatric and Preventive Dentistry, Meenakshi Ammal Dental College, MAHER, Chennai, Tamil Nadu, India.
Department of Pediatric and Preventive Dentistry, SRM Dental College, Chennai, Tamil Nadu, India.
Int J Clin Pediatr Dent. 2021 May-Jun;14(3):388-392. doi: 10.5005/jp-journals-10005-1951.
"Lesion sterilization and tissue repair" (LSTR) is a non-instrumentation endodontic treatment modality that has recently gained popularity with promising results in several clinical trials. However, there is a dearth of evidence regarding the concentration of modified triple antibiotic paste (MTAP) to be used for the procedure.
To compare the clinical and radiographic efficacy of 1 mg/mL and 1 g/mL concentrations of MTAP (ciprofloxacin, metronidazole, and clindamycin) used in LSTR of primary molars.
Sixty-four infected primary molars in children between 4 years and 10 years of age were randomly allocated to two groups. Lesion sterilization and tissue repair at 1 mg/mL concentration of MTAP (group I) and 1 g/mL concentration of MTAP (group II) was performed. Clinical and radiographic outcomes were evaluated using Coll and Sadrian's criteria at 10 days, 1 month, and 3 months and the results were tabulated.
The data obtained were subjected to statistical analysis with IBM. SPSS statistics software 23.0 Version. To test the significance in categorical data, a Chi-square test was used. The probability value of 0.05 was considered significant.
At the end of 3 months review, clinical success rates of group I and group II were 84.4 and 90.6%, respectively, and radiographic evaluation showed group I-78.1% and group II-90.6%.
Both 1 mg/mL and 1 g/mL concentrations of MTAP used in LSTR of primary molars had similar success rates with no statistically significant difference.
Lesion sterilization and tissue repair when found to be equally effective in less concentration may aid in achieving adequate infection control with the least detrimental effect on the remaining vital pulp and periradicular structures. In addition, this circumvents the systemic administration of potent antibiotics thus combating antibiotic resistance.
Shankar K, Ramkumar H, Dhakshinamoorthy S, Comparison of Modified Triple Antibiotic Paste in Two Concentrations for Lesion Sterilization and Tissue Repair in Primary Molars: An Interventional Randomized Clinical Trial. Int J Clin Pediatr Dent 2021;14(3):388-392.
“病变清除与组织修复”（LSTR）是一种非器械性牙髓治疗方法，最近在多项临床试验中取得了令人满意的结果，因而受到广泛关注。然而，关于该治疗过程中所用改良三联抗生素糊剂（MTAP）浓度的证据却十分匮乏。
比较1mg/mL和1g/mL浓度的MTAP（环丙沙星、甲硝唑和克林霉素）用于乳牙LSTR的临床和影像学疗效。
将64颗4至10岁儿童的感染乳牙随机分为两组。分别用1mg/mL浓度的MTAP（第一组）和1g/mL浓度的MTAP（第二组）进行病变清除与组织修复。在10天、1个月和3个月时，采用Coll和Sadrian标准评估临床和影像学结果，并将结果列表。
使用IBM SPSS统计软件23.0版本对所得数据进行统计分析。为检验分类数据的显著性，采用卡方检验。概率值0.05被视为具有显著性。
在3个月的复查结束时，第一组和第二组的临床成功率分别为84.4%和90.6%，影像学评估显示第一组为78.1%，第二组为90.6%。
1mg/mL和1g/mL浓度的MTAP用于乳牙LSTR的成功率相似，无统计学显著差异。
当发现较低浓度的病变清除与组织修复同样有效时，有助于在对剩余活髓和根尖周结构影响最小的情况下实现充分的感染控制。此外，这避免了强效抗生素的全身给药，从而对抗抗生素耐药性。
Shankar K, Ramkumar H, Dhakshinamoorthy S, 两种浓度改良三联抗生素糊剂用于乳牙病变清除与组织修复的比较：一项干预性随机临床试验。《国际临床儿科牙科学杂志》2021年；14(3):388 - 392。
