接受奥美拉唑与泮托拉唑治疗的房颤患者中达比加群的血药浓度：有差异吗？ - Suppr

Dabigatran levels in omeprazole versus pantoprazole-treated patients with atrial fibrillation: is there a difference?

作者信息

Bolek Tomáš, Samoš Matej, Škorňová Ingrid, Schnierer Martin, Lipták Peter, Bánovčin Peter, Urban Lukáš, Staško Ján, Kubisz Peter, Galajda Peter, Mokán Marián

机构信息

Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Kollarova 2, 036 59, Martin, Slovak Republic.

National Centre of Hemostasis and Thrombosis, Department of Hematology and Blood Transfusion, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic.

出版信息

Eur J Clin Pharmacol. 2019 Jun;75(6):875-877. doi: 10.1007/s00228-019-02647-8. Epub 2019 Feb 12.

DOI:10.1007/s00228-019-02647-8

PMID:30747244

Abstract

摘要

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Dabigatran levels in omeprazole versus pantoprazole-treated patients with atrial fibrillation: is there a difference?接受奥美拉唑与泮托拉唑治疗的房颤患者中达比加群的血药浓度：有差异吗？

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Comparison of omeprazole and pantoprazole influence on a high 150-mg clopidogrel maintenance dose the PACA (Proton Pump Inhibitors And Clopidogrel Association) prospective randomized study.奥美拉唑与泮托拉唑对150毫克氯吡格雷高维持剂量影响的比较：PACA（质子泵抑制剂与氯吡格雷关联）前瞻性随机研究。

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Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine.质子泵抑制剂奥美拉唑和泮托拉唑对文拉法辛细胞色素 P450 介导的代谢的影响。

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Proton pump inhibitors and osteoporosis risk: exploring the role of TRPM7 channel.质子泵抑制剂与骨质疏松风险：探索 TRPM7 通道的作用。

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Uninterrupted dabigatran versus warfarin in the treatment of intracardiac thrombus in patients with non-valvular atrial fibrillation.非瓣膜性心房颤动患者中心内血栓治疗中达比加群与华法林的不间断治疗对比

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Does proton pump inhibition change the on-treatment anti-Xa activity in xabans-treated patients with atrial fibrillation? A pilot study.质子泵抑制剂是否会改变接受 Xabans 治疗的房颤患者的治疗后抗 Xa 活性？一项初步研究。

J Thromb Thrombolysis. 2019 Jan;47(1):140-145. doi: 10.1007/s11239-018-1748-5.

Proton Pump Inhibition in Patients Treated With Novel Antithrombotic Drugs: Should We Worry About Thrombosis?质子泵抑制剂在新型抗血栓药物治疗患者中的应用：我们是否应该担心血栓形成？

J Cardiovasc Pharmacol. 2018 Jul;72(1):71-76. doi: 10.1097/FJC.0000000000000593.

Influence of proton pump inhibitors on blood dabigatran concentrations in Japanese patients with non-valvular atrial fibrillation.质子泵抑制剂对日本非瓣膜性心房颤动患者血液中达比加群浓度的影响。

J Arrhythm. 2017 Dec;33(6):619-623. doi: 10.1016/j.joa.2017.07.013. Epub 2017 Oct 12.

The Impact of Proton Pump Inhibition on Dabigatran Levels in Patients With Atrial Fibrillation.质子泵抑制剂对房颤患者达比加群水平的影响。

Am J Ther. 2019 May/Jun;26(3):e308-e313. doi: 10.1097/MJT.0000000000000599.

The potential drug-drug interaction between proton pump inhibitors and warfarin.质子泵抑制剂与华法林之间潜在的药物相互作用。

Pharmacoepidemiol Drug Saf. 2015 Dec;24(12):1337-40. doi: 10.1002/pds.3881. Epub 2015 Sep 23.

In vitro and in vivo evaluation of drug-drug interaction between dabigatran and proton pump inhibitors.达比加群与质子泵抑制剂之间药物相互作用的体外和体内评估。

Fundam Clin Pharmacol. 2015 Dec;29(6):604-14. doi: 10.1111/fcp.12154. Epub 2015 Oct 7.

Prevention of Dabigatran-Related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study.胃保护剂预防达比加群相关胃肠道出血的效果：一项基于人群的研究。

Gastroenterology. 2015 Sep;149(3):586-95.e3. doi: 10.1053/j.gastro.2015.05.002. Epub 2015 May 8.

Monitoring of dabigatran therapy using Hemoclot(®) Thrombin Inhibitor assay in patients with atrial fibrillation.使用Hemoclot（®）凝血酶抑制剂检测法监测心房颤动患者的达比加群治疗情况。

J Thromb Thrombolysis. 2015 Jan;39(1):95-100. doi: 10.1007/s11239-014-1125-y.

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Dabigatran levels in omeprazole versus pantoprazole-treated patients with atrial fibrillation: is there a difference?

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