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Possible involvement of nuclei in cadmium-induced modifications of cultured cells.

作者信息

Fighetti M A, Miele M, Montella A, Desole M S, Congiu A M, Anania V

机构信息

Institutes of Pharmacology, University of Sassari, Italy.

出版信息

Arch Toxicol. 1988;62(6):476-8. doi: 10.1007/BF00288354.

DOI:10.1007/BF00288354
PMID:3074747
Abstract

Reduced metaphase number and shortening of metaphase chromosomes were detected in McCoy cells exposed to 100 microM CdSO4 (maximal exposure time: 7 h). One hour exposure to 109Cd was enough to label the cell nucleus. This possibly suggests an early nuclear involvement in Cd-induced cell damage.

摘要

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本文引用的文献

1
Cd2+ responses of cultured human blood cells.
Toxicol Appl Pharmacol. 1983 Jun 30;69(2):214-24. doi: 10.1016/0041-008x(83)90302-2.
2
Cadmium toxicity and lipid peroxidation in isolated rat hepatocytes.镉对离体大鼠肝细胞的毒性作用及脂质过氧化反应
Toxicol Appl Pharmacol. 1980 May;53(3):470-80. doi: 10.1016/0041-008x(80)90359-2.
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The effects of cadmium, manganese and aluminium on sodium-potassium-activated and magnesium-activated adenosine triphosphatase activity and choline uptake in rat brain synaptosomes.
Biochem Pharmacol. 1980 Feb;29(2):141-6. doi: 10.1016/0006-2952(80)90321-4.
4
Fluorescent phallotoxin, a tool for the visualization of cellular actin.荧光鬼笔毒素,一种用于可视化细胞肌动蛋白的工具。
Proc Natl Acad Sci U S A. 1979 Sep;76(9):4498-502. doi: 10.1073/pnas.76.9.4498.
5
Toxic substances and cell membrane function.有毒物质与细胞膜功能
Fed Proc. 1979 Jul;38(8):2220-5.