Minarich Michael J, Schwarz Roderich E
Am Surg. 2018 Nov 1;84(11):1734-1740.
Pancreatic stump leak after distal pancreatectomy (DP) is a major determinant for impaired postoperative recovery. Factors influencing pancreatic fistula (PF) occurrence remain of interest. Prospectively collected data from an academic surgical oncology practice were examined for predictors of PF. Seventy-five of 294 pancreatectomy patients underwent DP (26%). There were 33 men and 42 women, with a median age of 61 years (range: 18-85 years). Underlying conditions included cancer (60%) and benign processes (40%). Resections were comprising open DP (64%), laparoscopic DP (21%), and open multivisceral resections (15%). Of 21 cases with postoperative complications (28%, no death), six were PFs (8%, 2 grade A and 4 grade B). The median length of stay was six days (4-24). The PF rate was 2.0 per cent in 50 patients after sutured fish-mouth closures, but 20 per cent in cases using other techniques including stapling ( = 0.007); no other variable was linked to PF occurrence. Length of stay was linked to complications, resection extent, malignancy, and transfusions (all at < 0.02), but not to PF. PF rate after DP in this experience is unaffected by splenic vessel resection but seems to be minimized through a sutured fish-mouth closure technique.
胰体尾切除术后胰残端渗漏是术后恢复受损的主要决定因素。影响胰瘘发生的因素一直备受关注。对前瞻性收集的来自学术性外科肿瘤学实践的数据进行分析,以寻找胰瘘的预测因素。294例胰腺切除术患者中有75例接受了胰体尾切除术(26%)。其中男性33例,女性42例,中位年龄61岁(范围:18 - 85岁)。基础疾病包括癌症(60%)和良性疾病(40%)。手术方式包括开放性胰体尾切除术(64%)、腹腔镜胰体尾切除术(21%)和开放性多脏器切除术(15%)。21例术后出现并发症(28%,无死亡),其中6例为胰瘘(8%,2例A级和4例B级)。中位住院时间为6天(4 - 24天)。采用缝合鱼口状闭合术的50例患者胰瘘发生率为2.0%,而采用包括吻合器在内的其他技术的患者胰瘘发生率为20%(P = 0.007);没有其他变量与胰瘘发生相关。住院时间与并发症、切除范围、恶性肿瘤及输血有关(均P < 0.02),但与胰瘘无关。在本研究中,胰体尾切除术后的胰瘘发生率不受脾血管切除的影响,但似乎通过缝合鱼口状闭合术可降至最低。