Brain Autoimmunity Group, Kids Neuroscience Centre at Kids Research, The Children's Hospital, Westmead, New South Wales.
Sydney Medical School, University of Sydney, Sydney, New South Wales.
Eur J Neurol. 2019 Aug;26(8):1137-e75. doi: 10.1111/ene.13932. Epub 2019 Mar 5.
Antibodies to myelin oligodendrocyte glycoprotein (MOG) have been identified in both children and adults with demyelination, with a strong association with bilateral or recurrent optic neuritis (ON). However, the full clinical spectrum of this newly described condition is unknown. We sought to describe non-ON inflammatory ophthalmological presentations such as uveitis and optic perineuritis in the context of MOG antibody seropositivity.
Using a live cell-based assay analysed by flow cytometry, we identified seropositive patients referred for MOG antibody testing in Australasia between 2014 and 2017. We identified four MOG antibody-positive patients with non-ON inflammatory ophthalmological presentations and present their detailed clinical information in this case series.
Three patients had uveitis either in association with, or remote from, ON. One patient had optic perineuritis and peripheral ulcerative keratitis. We describe the presentation, examination, investigation findings and clinical course of these four patients.
Recognition of these novel clinical associations may expand the clinical spectrum of MOG antibody-associated presentations. An expedited diagnosis may guide the management of these complex patients.
髓鞘少突胶质细胞糖蛋白（MOG）抗体已在儿童和成人脱髓鞘患者中被发现，其与双侧或复发性视神经炎（ON）有密切关联。然而，这种新描述疾病的完整临床谱尚不清楚。我们试图在 MOG 抗体阳性的情况下描述非 ON 炎症性眼表表现，如葡萄膜炎和视神经鞘膜炎。
我们使用活细胞基于流式细胞术分析的方法，鉴定了 2014 年至 2017 年期间在澳大拉西亚地区因 MOG 抗体检测而转诊的血清阳性患者。我们确定了 4 例 MOG 抗体阳性且伴有非 ON 炎症性眼表表现的患者，并在本病例系列中详细介绍了他们的临床信息。
3 例患者的葡萄膜炎与 ON 相关或不相关。1 例患者患有视神经鞘膜炎和周边溃疡性角膜炎。我们描述了这 4 名患者的表现、检查、检查结果和临床过程。
认识到这些新的临床关联可能会扩展 MOG 抗体相关表现的临床谱。快速诊断可能有助于管理这些复杂的患者。
