去神经支配引起的电细胞细胞膜脂质组成的改变。

Modification of electrocyte membrane lipid composition induced by denervation.

Quintana E G, Somló C, Hassón-Voloch A

Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Brasil.

Braz J Med Biol Res. 1988;21(6):1163-71.

Abstract

We determined the effect of denervation on the lipid composition of the main electric organ and electrocyte postsynaptic membrane vesicles of Electrophorus electricus. 2. Lipid extracts of whole electric organ contain mainly cholesterol, triglycerides, phosphatidylcholine and phosphatidylethanolamine. After 30 days of denervation, the lipid composition of whole electric organ did not change appreciably. 3. Lipid extracts of the membrane vesicles were similar, except that they contained mainly free fatty acids rather than triglycerides. After 30 days of denervation, cholesterol concentration was increased and phospholipids were decreased in the membrane fraction, with higher relative concentrations of phosphatidylethanolamine and cerebrosides. 4. These results suggest that electrocyte membrane fluidity and permeability will change after 30 days of denervation.

摘要

我们确定了去神经支配对电鳗主要发电器官和电细胞突触后膜囊泡脂质组成的影响。2. 整个发电器官的脂质提取物主要包含胆固醇、甘油三酯、磷脂酰胆碱和磷脂酰乙醇胺。去神经支配30天后，整个发电器官的脂质组成没有明显变化。3. 膜囊泡的脂质提取物相似，只是它们主要含有游离脂肪酸而非甘油三酯。去神经支配30天后，膜组分中的胆固醇浓度增加，磷脂减少，磷脂酰乙醇胺和脑苷脂的相对浓度更高。4. 这些结果表明，去神经支配30天后，电细胞膜的流动性和通透性将会改变。