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微生物铁转运化合物的配位化学：红酵母酸与皮利曼红酵母中的铁摄取

Coordination chemistry of microbial iron transport compounds: rhodotorulic acid and iron uptake in Rhodotorula pilimanae.

作者信息

Carrano C J, Raymond K N

出版信息

J Bacteriol. 1978 Oct;136(1):69-74. doi: 10.1128/jb.136.1.69-74.1978.

DOI:10.1128/jb.136.1.69-74.1978
PMID:30750
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC218633/
Abstract

The mechanism by which iron uptake is facilitated by the siderophore rhodotorulic acid (RA) in the yeast Rhodotorula pilimanae was investigated with radioactively labeled Fe and RA and kinetically inert, chromic-substituted RA complexes. The weight of the evidence supports a model in which RA mediates iron transport to the cell but does not actually transport iron into the cell. It is proposed that RA exchanges the ferric ion at the cell surface with a membrane-bound chelating agent that completes the active transport of iron into the cell. Uptake of 55Fe in ferric rhodotorulate was much more rapid than uptake of RA itself. Two exchange-inert chromic complexes of RA showed no uptake.

摘要

利用放射性标记的铁和罗地酸（RA）以及动力学惰性的铬取代RA络合物，研究了酵母皮膜红酵母中罗地酸（RA）促进铁摄取的机制。大量证据支持这样一个模型，即RA介导铁向细胞的转运，但实际上并不将铁转运到细胞内。有人提出，RA在细胞表面用一种膜结合螯合剂交换铁离子，该螯合剂完成铁向细胞的主动转运。55Fe在罗地酸铁中的摄取比RA本身的摄取要快得多。两种RA的交换惰性铬络合物没有摄取现象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb51/218633/37084d91ddc0/jbacter00287-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb51/218633/37084d91ddc0/jbacter00287-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb51/218633/37084d91ddc0/jbacter00287-0081-a.jpg

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