绿粘帚霉中嗜铁素介导的铁（III）摄取。2. 单异羟肟酸铁和二异羟肟酸铁作为铁转运剂的作用。

Siderophore mediated iron(III) uptake in Gliocladium virens. 2. Role of ferric mono- and dihydroxamates as iron transport agents.

作者信息

Jalal M A, Love S K, van der Helm D

出版信息

J Inorg Biochem. 1987 Apr;29(4):259-67. doi: 10.1016/0162-0134(87)80033-8.

Abstract

The Fe(III) transport properties of the monohydroxamates, cis-fusarinine (cF) and trans-fusarinine (tF), and the dihydroxamate, dimerum acid (DA), the major siderophores of the fungus, Gliocladium virens ATCC 24290, have been investigated using labeled ferric siderophores. Fe(cF)3, Fe(tF)3 and Fe2(DA)3 (and also one of the minor trihydroxamates, ferricrocin) transport extracellular 55Fe(III) very efficiently into the fungus. Coprogen, another minor trihydroxamate, behaves as a weak Fe(III)-transporting agent. The respiratory poisons, KCN and NaN3, significantly inhibit uptake activity, indicating that the Fe(III) uptake mediated by Fe(cF)3, Fe(tF)3, and Fe2(DA)3 involves active transport systems in the membrane. A number of fungal species, both producers and nonproducers of cF, tF, and DA, show ability at varying degrees to transport 55Fe(III) bound to these siderophores.

摘要

已使用标记的铁载体研究了单异羟肟酸酯顺式镰刀菌素（cF）和反式镰刀菌素（tF）以及双异羟肟酸酯二聚酸（DA）（真菌绿粘帚霉ATCC 24290的主要铁载体）的铁（III）转运特性。Fe（cF）3、Fe（tF）3和Fe2（DA）3（以及一种次要的三异羟肟酸酯铁载体菌素）能非常有效地将细胞外55Fe（III）转运到真菌中。粪卟啉原（另一种次要的三异羟肟酸酯）是一种较弱的铁（III）转运剂。呼吸毒物KCN和NaN3能显著抑制摄取活性，这表明由Fe（cF）3、Fe（tF）3和Fe2（DA）3介导的铁（III）摄取涉及膜中的主动转运系统。许多真菌物种，无论是否产生cF、tF和DA，都表现出不同程度转运与这些铁载体结合的55Fe（III）的能力。