Grupo GICRIM, Programa de Investigación Criminal , Universidad Manuela Beltrán , Bogotá , Colombia.
Departamento de Química, Facultad de Ciencias , Universidad Nacional de Colombia , Bogotá , Colombia.
Crit Rev Anal Chem. 2019;49(5):383-394. doi: 10.1080/10408347.2018.1534200. Epub 2019 Feb 12.
This article is based on a review of the literature and our own experience with toxicological molecules. We explain the nature of calix[n]arenes and as their recognized properties are used to detect compounds of toxicological interest, mainly the most important pesticide families such as organophosphorated, organochlorine compounds, pyrethroid insecticides, carbamate fungicides, and herbicides, using different techniques. In addition, we show the role of the macrocycle and its interactions, and the advantage of using this type of compound for improving conventional techniques, where the phenomenon of recognition is very important, such as chromatography, solid-phased extraction, and the development of specific sensors, among others and Even we also show the use of this macrocycle for detoxication procedures . In this way, we display as the multiple possibilities of functionalization of the calix[n]arenes makes these versatile molecules in the phenomena of specific recognition. Finally, This review highlights the main analytical methods reported in the literature for determination of plaguicides by host-guest interaction with calixarenes. In this way, among the available analytical tools, chromatographic, and electrochemical-based methods are the most used techniques for the detection and to quantify plaguicides using calixarenes.
本文基于对文献的回顾和我们自己在毒理学分子方面的经验。我们解释了杯芳烃的性质，以及它们被认可的特性如何被用于检测具有毒理学意义的化合物，主要是最重要的几大农药家族，如有机磷、有机氯化合物、拟除虫菊酯杀虫剂、氨基甲酸酯类杀菌剂和除草剂，同时使用了不同的技术。此外，我们展示了大环及其相互作用的作用，以及使用这种类型的化合物来改进常规技术的优势，在这些技术中，识别现象非常重要，如色谱法、固相萃取法和特定传感器的开发等，甚至我们还展示了这种大环在解毒程序中的应用。 因此，我们展示了杯芳烃的多种可能的功能化方式，使这些多功能分子在特定识别现象中具有通用性。最后，本文重点介绍了文献中报道的基于主体-客体相互作用用杯芳烃测定农药的主要分析方法。 因此，在现有的分析工具中，基于色谱法和电化学的方法是最常用于检测和定量使用杯芳烃的农药的技术。
