Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, PL-01 224 Warszawa, Poland.
Chem Commun (Camb). 2009 Oct 21(39):5799-813. doi: 10.1039/b910331g. Epub 2009 Aug 19.
Among all crystalline complexes of calix-type calix[n]arenes those with organic molecules which are biologically relevant are especially of interest due to their potential medical and pharmaceutical applications. The co-crystallization of drugs with water-soluble calixarenes offers the opportunity to modify chemical and physical properties of APIs (active pharmaceutical ingredients) and to control drug conformation. Such co-crystallization can improve solubility, bioavailability and stability of pharmaceutically active molecules and/or eliminate polymorphism. In this article the solid-state interactions between calixarene hosts and biologically relevant guest molecules are summarized for the currently available structures solved by single-crystal X-ray crystallography.
由于其潜在的医疗和制药应用，所有杯芳烃型杯[ n ]芳烃的晶体复合物中，与具有生物学相关性的有机分子的复合物尤其受到关注。水溶性杯芳烃与药物的共结晶为修饰 API（活性药物成分）的化学和物理性质以及控制药物构象提供了机会。这种共结晶可以提高药用活性分子的溶解度、生物利用度和稳定性，或者消除多晶型现象。本文总结了目前通过单晶 X 射线晶体学解决的结构中杯芳烃主体与具有生物学相关性的客体分子之间的固态相互作用。
