葡萄糖-6-磷酸脱氢酶缺乏症患者中伯氨喹诱导溶血的临床谱：一项基于巴西亚马逊地区9年住院病例的研究
Clinical Spectrum of Primaquine-induced Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency: A 9-Year Hospitalization-based Study From the Brazilian Amazon.
作者信息
Brito-Sousa Jose Diego, Santos Thalie C, Avalos Sara, Fontecha Gustavo, Melo Gisely C, Val Fernando, Siqueira André M, Alecrim Graça C, Bassat Quique, Lacerda Marcus V G, Monteiro Wuelton M
机构信息
Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Brazil.
Escola Superior de Ciências da Saúde, Universidade do Estado do Amazonas, Manaus, Brazil.
出版信息
Clin Infect Dis. 2019 Sep 27;69(8):1440-1442. doi: 10.1093/cid/ciz122.
Despite glucose-6-phosphate dehydrogenase (G6PD) deficiency prevalence of 5% in the Amazon, primaquine is administered without G6PD screening. This is an important cause of hospitalization among Plasmodium vivax-infected individuals, leading to life-threatening anemia and acute renal failure across endemic areas. In Manaus, the frequency of primaquine-induced hemolysis was 85.2 cases per 100 000 primaquine users.
尽管在亚马逊地区葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症的患病率为5%，但在使用伯氨喹时并未进行G6PD筛查。这是间日疟原虫感染个体住院的一个重要原因，在流行地区会导致危及生命的贫血和急性肾衰竭。在玛瑙斯，每10万名伯氨喹使用者中伯氨喹诱发溶血的发生率为85.2例。
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