巴西西部亚马逊地区葡萄糖-6-磷酸脱氢酶缺乏症患者中糖尿病和空腹血糖受损的高发生率
High frequency of diabetes and impaired fasting glucose in patients with glucose-6-phosphate dehydrogenase deficiency in the Western brazilian Amazon.
作者信息
Santana Marli S, Monteiro Wuelton M, Costa Mônica R F, Sampaio Vanderson S, Brito Marcelo A M, Lacerda Marcus V G, Alecrim Maria G C
机构信息
Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil
Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
出版信息
Am J Trop Med Hyg. 2014 Jul;91(1):74-6. doi: 10.4269/ajtmh.13-0032. Epub 2014 May 27.
Abstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, and it has a significant prevalence in the male population (X chromosome linked). The purpose of this study was to estimate the frequency of impaired fasting glucose and diabetes among G6PD-deficient persons in Manaus, Brazil, an area in the Western Brazilian Amazon to which malaria is endemic. Glucose-6-phosphate dehydrogenase-deficient males had more impaired fasting glucose and diabetes. This feature could be used as a screening tool for G6PD-deficient persons who are unable to use primaquine for the radical cure of Plasmodium vivax malaria.
摘要
葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症是人类最常见的遗传异常之一，在男性人群（X染色体连锁）中具有较高的患病率。本研究的目的是估计巴西马瑙斯（巴西西部亚马逊地区，疟疾流行）G6PD缺乏者中空腹血糖受损和糖尿病的发生率。G6PD缺乏的男性空腹血糖受损和患糖尿病的情况更多。这一特征可作为一种筛查工具，用于那些不能使用伯氨喹进行间日疟原虫疟疾根治的G6PD缺乏者。
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