Experience with captopril treatment.

Experience with the use of foreign (Capoten Lopirin; Squibb) and Hungarian (Tensiomin; EGIS) captopril preparations is reported. It was found that the first dose of captopril resulted in a larger blood pressure decrease in hypertensive patients with a high blood renin level. A linear correlation was observed between the blood renin level before treatment and the captopril induced blood pressure decrease following the first dose. Captopril monotherapy lowered the blood pressure effectively without significant pulse rate change in patients whose blood pressure was difficult to influence with combined treatment containing no captopril. This paper reports on the area of indications and side-effects of the drug.