Giovanni Artini Paolo, Monteleone Patrizia, Parisen Toldin Maria Rosaria, Matteucci Cristiana, Ruggiero Maria, Cela Vito, Genazzani Andrea Riccardo
a University of Pisa, Department of Reproductive Medicine and Child Development, Division of Obstetrics & Gynecology, S. Chiara Hospital, Via Roma 56, 56126 Pisa, Italy.
b Department of Reproductive Medicine & Child Development, Division of Obstetrics & Gynecology, University of Pisa, Via Roma 67, 56126 Pisa, Italy.
Expert Rev Endocrinol Metab. 2007 Mar;2(2):215-223. doi: 10.1586/17446651.2.2.215.
Ovarian folliculogenesis is regulated by a fine balance between endocrine and intraovarian factors. In this review, we focus on the role of growth factors in physiological folliculogenesis and in polycystic ovaries. Recent evidence shows that the main systems implicated in polycystic ovary folliculogenesis are the growth hormone and insulin-like growth factor system, vascular endothelial growth factor, and the transforming growth factor-β family. Growth hormone and the insulin-like growth factor system could affect follicular development and oocyte maturation if their balance was altered, while vascular endothelial growth factor is implied in follicular dominance by providing an increasing vascular supply. The transforming growth factor-β family is composed of various molecules, which have different roles in cellular proliferation. Finally, a series of different factors seem to be involved in altered polycystic ovary follicular growth.
卵巢卵泡生成受内分泌和卵巢内因素之间的精细平衡调节。在本综述中，我们重点关注生长因子在生理性卵泡生成和多囊卵巢中的作用。最近的证据表明，多囊卵巢卵泡生成中涉及的主要系统是生长激素和胰岛素样生长因子系统、血管内皮生长因子以及转化生长因子-β家族。如果生长激素和胰岛素样生长因子系统的平衡发生改变，它们可能会影响卵泡发育和卵母细胞成熟，而血管内皮生长因子通过增加血管供应参与卵泡优势化过程。转化生长因子-β家族由多种分子组成，它们在细胞增殖中具有不同作用。最后，一系列不同因素似乎与多囊卵巢卵泡生长改变有关。
