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鳞状细胞癌中的肌肉特异性FXR1亚型

Muscle-Specific FXR1 Isoforms in Squamous Cell Cancer.

作者信息

McClure Jesse J, Palanisamy Viswanathan

机构信息

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

出版信息

Trends Cancer. 2019 Feb;5(2):82-84. doi: 10.1016/j.trecan.2018.12.001. Epub 2018 Dec 21.

DOI:10.1016/j.trecan.2018.12.001
PMID:30755307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6404231/
Abstract

The RNA-binding protein fragile-X mental retardation autosomal 1 (FXR1) is upregulated in head and neck squamous cell carcinomas (HNSCCs) and expressed as at least seven isoforms in humans. Only two of these isoforms are capable of binding to RNA containing G-quadruplex structures. We suggest that these unique isoforms play a role in the pathogenesis of HNSCC.

摘要

RNA结合蛋白脆性X智力低下常染色体1（FXR1）在头颈部鳞状细胞癌（HNSCC）中上调，在人类中至少以七种异构体形式表达。这些异构体中只有两种能够结合含有G-四链体结构的RNA。我们认为这些独特的异构体在HNSCC的发病机制中起作用。

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本文引用的文献

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RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC.RNA结合蛋白FXR1通过调节p21和TERC RNA来绕过p53介导的口腔鳞状细胞癌细胞衰老。
PLoS Genet. 2016 Sep 8;12(9):e1006306. doi: 10.1371/journal.pgen.1006306. eCollection 2016 Sep.
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MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells.在骨骼肌细胞分化过程中，微小RNA-222通过Rbm24调节肌肉可变剪接。
Cell Death Dis. 2016 Feb 4;7(2):e2086. doi: 10.1038/cddis.2016.10.
3
The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers.RNA结合蛋白FXR1是3q26 - 29扩增子中的一个新驱动因子，并预示人类癌症预后不良。
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3469-74. doi: 10.1073/pnas.1421975112. Epub 2015 Mar 2.
4
A novel role for the RNA-binding protein FXR1P in myoblasts cell-cycle progression by modulating p21/Cdkn1a/Cip1/Waf1 mRNA stability.RNA 结合蛋白 FXR1P 通过调节 p21/Cdkn1a/Cip1/Waf1 mRNA 稳定性在成肌细胞细胞周期进程中发挥新作用。
PLoS Genet. 2013 Mar;9(3):e1003367. doi: 10.1371/journal.pgen.1003367. Epub 2013 Mar 21.
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Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions.Rbfox 调控的可变剪接对于斑马鱼心脏和骨骼肌功能至关重要。
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J Med Genet. 2008 Oct;45(10):679-85. doi: 10.1136/jmg.2008.060541. Epub 2008 Jul 15.
7
Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lung.位于3q26 - 27扩增子上的FXR1、CLAPM1和EIF4G基因在肺鳞状细胞癌中经常过表达。
Int J Cancer. 2007 Jun 15;120(12):2538-44. doi: 10.1002/ijc.22585.
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Muscle specific fragile X related protein 1 isoforms are sequestered in the nucleus of undifferentiated myoblast.肌肉特异性脆性X相关蛋白1亚型被隔离在未分化成肌细胞的细胞核中。
BMC Genet. 2000;1:4. doi: 10.1186/1471-2156-1-4. Epub 2000 Dec 7.
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