类风湿关节炎与麦相关疾病特征性血清抗体的重叠。
Overlap of Characteristic Serological Antibodies in Rheumatoid Arthritis and Wheat-Related Disorders.
机构信息
Vibrant America LLC., San Carlos, CA, USA.
Vibrant Sciences, LLC., San Carlos, CA, USA.
出版信息
Dis Markers. 2019 Jan 10;2019:4089178. doi: 10.1155/2019/4089178. eCollection 2019.
BACKGROUND AND AIMS
Rheumatoid arthritis (RA) and celiac disease (CD) are members of the autoimmune disease family while they have been shown to share multiple aspects in epidemiology and clinical manifestations. The aim of this study was to assess the presence of wheat protein antibodies in RA seropositive subjects and the presence of RA diagnostic markers in subjects with seropositive wheat-related disorders including CD.
METHODS
Serum samples were collected from 844 subjects with joint pain and/or gastrointestinal symptoms and tested by a CD panel (anti-tTG and anti-DGP), a Wheat Zoomer (WZ) antibody panel (IgG/IgA to 14 wheat proteins), and a RA panel (anti-CCP and anti-RF). Retrospective analysis was completed using de-identified clinical data and test results.
RESULTS
The prevalence of RA markers was first investigated in CD- or WZ-positive subjects and negative controls. 49 subjects were seropositive in the CD panel with 10 (20%) RA positivity. 605 subjects were seropositive in the WZ panel with 106 (18%) RA positivity. 222 subjects were seronegative in either panels with 12 (6%) RA positivity. Next, the frequency of the CD markers and the clinically relevant wheat protein antibodies were investigated in the RA-positive subjects and negative controls. 128 subjects in this cohort were seropositive in the RA panel with 10 (8%) CD positivity and 106 (83%) WZ positivity, compared to 716 RA seronegative controls with 39 (5%) CD positivity and 499 (70%) WZ positivity.
CONCLUSIONS
Our data presents an apparent trend of overlapped serological antibody biomarker positivity in RA and wheat-related disorders.
背景和目的
类风湿关节炎（RA）和乳糜泻（CD）是自身免疫性疾病家族的成员，尽管它们在流行病学和临床表现方面有多个共同之处。本研究旨在评估 RA 血清阳性患者中是否存在小麦蛋白抗体，以及在包括 CD 在内的血清阳性与小麦相关疾病患者中是否存在 RA 诊断标志物。
方法
收集了 844 例关节痛和/或胃肠道症状的患者血清样本，通过 CD 面板（抗 tTG 和抗 DGP）、小麦 Zoomer（WZ）抗体面板（针对 14 种小麦蛋白的 IgG/IgA）和 RA 面板（抗 CCP 和抗 RF）进行检测。使用去识别的临床数据和检测结果进行回顾性分析。
结果
首先在 CD 或 WZ 阳性患者和阴性对照中调查 RA 标志物的患病率。在 CD 面板中，有 49 例患者血清阳性，其中 10 例（20%）RA 阳性。在 WZ 面板中，有 605 例患者血清阳性，其中 106 例（18%）RA 阳性。在两个面板中，有 222 例患者血清阴性，其中 12 例（6%）RA 阳性。接下来，在 RA 阳性患者和阴性对照中调查 CD 标志物和临床相关的小麦蛋白抗体的频率。在该队列中，有 128 例患者在 RA 面板中血清阳性，其中 10 例（8%）CD 阳性，106 例（83%）WZ 阳性，而在 716 例 RA 血清阴性对照中，有 39 例（5%）CD 阳性，499 例（70%）WZ 阳性。
结论
我们的数据表明 RA 和与小麦相关的疾病中存在明显的重叠血清抗体生物标志物阳性趋势。
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