Markman Timothy M, Markman Maurie
Department of Medicine, Cardiovascular Division, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA.
Cancer Treatment Centers of America at Eastern Regional Medical Center, Philadelphia, PA, USA.
F1000Res. 2019 Jan 30;8. doi: 10.12688/f1000research.14542.1. eCollection 2019.
Traditional chemotherapeutic agents and newer targeted therapies for cancer have the potential to cause cardiovascular toxicities. These toxicities can result in arrhythmias, heart failure, vascular toxicity, and even death. It is important for oncologists and cardiologists to understand the basic diagnostic and management strategies to employ when these toxicities occur. While anti-neoplastic therapy occasionally must be discontinued in this setting, it can often be maintained with caution and careful monitoring. In the second of this two-part review series, we focus on the management of cardiovascular toxicity from anthracyclines, HER2/ErbB2 inhibitors, immune checkpoint inhibitors, and vascular endothelial growth factor inhibitors.
传统的癌症化疗药物和新型靶向治疗药物都有可能导致心血管毒性。这些毒性可引发心律失常、心力衰竭、血管毒性,甚至死亡。肿瘤学家和心脏病学家了解这些毒性发生时应采用的基本诊断和管理策略非常重要。虽然在这种情况下有时必须停用抗肿瘤治疗,但通常可以谨慎地维持治疗并进行密切监测。在这个两部分综述系列的第二篇中,我们重点关注蒽环类药物、HER2/ErbB2抑制剂、免疫检查点抑制剂和血管内皮生长因子抑制剂所致心血管毒性的管理。