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伪装成全身性疾病的慢性汞中毒:一例报告及文献复习

Chronic Mercury Intoxication Masquerading as Systemic Disease: A Case Report and Review of the Literature.

作者信息

Malek Alexandre, Aouad Krystel, El Khoury Rana, Halabi-Tawil Maya, Choucair Jacques

机构信息

Infectious Diseases Department, Saint Joseph University, Faculty of Medicine/Hotel Dieu De France Hospital, Beyrouth, Lebanon.

Université Pierre et Marie Curie, Paris, France.

出版信息

Eur J Case Rep Intern Med. 2017 May 24;4(6):000632. doi: 10.12890/2017_000623. eCollection 2017.

Abstract

BACKGROUND

Mercury is a highly toxic environmental metal that exists in three different forms: elemental, inorganic and organic. Intoxication occurs in either occupational or non-occupational settings, mainly after the inhalation of vapour and fumes in work places, laboratories or homes. Chronic mercury toxicity ranges from mild and insignificant to severe and life-threatening. We describe the case of a young male patient who presented with multiple organ dysfunction after chronic mercury exposure.

CASE PRESENTATION

We report the case of 28-year-old male artisanal gold miner who was admitted to hospital for severe neurological impairment associated with inflammatory bowel disease-like symptoms and a skin rash after mercury exposure. Symptomatic treatment and corticosteroid administration assured rapid clinical improvement. Chronic mercury poisoning can masquerade as an autoimmune or systemic inflammatory disease.

CONCLUSION

Physicians should be aware that low exposure to mercury, even from artisanal gold mining, may be harmful to health. Management can be simple without the need for aggressive or invasive therapeutic measures. Larger case series are required in order to establish a clear management plan.

LEARNING POINTS

Mercury intoxication has a wide the variety of clinical manifestations that may involve the neurological, gastrointestinal and dermatological systems.Therefore, it can mimic degenerative neurological conditions, autoimmune diseases, as well as metabolic and mitochondrial disorders.Once diagnosed, mercury intoxication is easily treated.

摘要

背景

汞是一种剧毒环境金属,以三种不同形式存在:元素汞、无机汞和有机汞。中毒发生在职业或非职业环境中,主要是在工作场所、实验室或家中吸入汞蒸气和烟雾之后。慢性汞中毒的程度从轻微且无明显影响到严重并危及生命不等。我们描述了一名年轻男性患者在慢性汞暴露后出现多器官功能障碍的病例。

病例介绍

我们报告了一名28岁男性手工淘金者的病例,他因汞暴露后出现严重神经功能损害、类似炎症性肠病的症状和皮疹而入院。对症治疗和给予皮质类固醇确保了临床症状迅速改善。慢性汞中毒可能伪装成自身免疫性或全身性炎症性疾病。

结论

医生应意识到,即使是来自手工淘金的低剂量汞暴露也可能对健康有害。管理措施可能很简单,无需采取激进或侵入性治疗措施。需要更大规模的病例系列研究以制定明确的管理计划。

经验教训

汞中毒有广泛的临床表现,可能累及神经、胃肠和皮肤系统。因此,它可以模仿退行性神经疾病、自身免疫性疾病以及代谢和线粒体疾病。一旦确诊,汞中毒很容易治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45ef/6346794/250e0d24eaf0/623_Fig1.jpg

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