胸腺肿瘤伴小脑变性

Thymic Carcinoma Associated with Cerebellar Degeneration.

作者信息

Cuartero Irene García, Galdeano Monica Rodríguez, Pinar Montserrat Pérez, Del Pozo Julián Solís García

机构信息

Department of Internal Medicine, Albacete University Hospital, Albacete, Spain.

Department of Internal Medicine, Villarrobledo General Hospital, Villarrobledo, Albacete, Spain.

出版信息

Eur J Case Rep Intern Med. 2018 Mar 21;5(3):000780. doi: 10.12890/2018_000780. eCollection 2018.

DOI:10.12890/2018_000780

PMID:30756016

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6346953/

Abstract

UNLABELLED

We present the case of a 57-year-old man with ataxia and clinical and radiological features of cerebellar degeneration. Computed tomography showed a mediastinal mass and the patient was diagnosed with thymic carcinoma. Paraneoplastic cerebellar degeneration is aninfrequent disorder and its association with thymic carcinoma very rare.

LEARNING POINTS

Unexplained subacute neurological symptoms in an adult patient should beconsidered in the possibility of a paraneoplastic syndrome. In patients over 50 years of age, acute or subacute cerebellar degeneration is paraneoplastic in 50% of cases.Small-cell lung cancer is the most common cancer-causing paraneoplastic cerebellar degeneration (PCD). Despite this, mediastinal tumours such as thymus neoplasms should not be ruled out in the differential diagnosis.Antineuronal antibodies are not detected in 40% of patients with PCD, sothe exclusion of other aetiologies or the demonstration of cancer formsthe basis of the final diagnosis.

摘要

未标注

我们报告一例57岁男性患者，患有共济失调以及小脑变性的临床和影像学特征。计算机断层扫描显示纵隔肿块，该患者被诊断为胸腺癌。副肿瘤性小脑变性是一种罕见疾病，其与胸腺癌的关联非常罕见。

学习要点

成年患者出现无法解释的亚急性神经症状时，应考虑副肿瘤综合征的可能性。在50岁以上的患者中，急性或亚急性小脑变性在50%的病例中为副肿瘤性。小细胞肺癌是导致副肿瘤性小脑变性（PCD）最常见的癌症。尽管如此，在鉴别诊断中不应排除纵隔肿瘤，如胸腺肿瘤。40%的PCD患者未检测到抗神经元抗体，因此排除其他病因或证实癌症是最终诊断的基础。