前列腺癌健康差异中的雄激素代谢基因。
Androgen metabolism genes in prostate cancer health disparities.
作者信息
Liu Wei, Liu Runhua, Wang Lizhong
机构信息
Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun 130041, PR China.
Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.
出版信息
Cancer Health Disparities. 2017;1:e1-e6. doi: 10.9777/rr.2017.10003. Epub 2017 Nov 18.
For men in the United States, prostate cancer is common, and newly diagnosed cases of prostate cancer outnumber those of all other cancer types. For prostate cancer, there are racial disparities between Caucasian Americans and African Americans. Androgens and androgen metabolism may be involved in these disparities as well as in the initiation and progression of prostate cancer. Here, we analyzed, in the Cancer Genome Atlas (TCGA) database, the mRNA expression of genes involved in androgen metabolism in prostate cancer based on the patient's race. The results revealed that expressions of and are higher but that , , , and are lower in African American prostate cancers than in those of Caucasian Americans. These genes may relate to the racial disparities associated with prostate cancer. However, the evidence require validation and functional analysis.
在美国男性中，前列腺癌很常见，新诊断出的前列腺癌病例数量超过所有其他癌症类型。对于前列腺癌，美国白人和非裔美国人之间存在种族差异。雄激素及其代谢可能与这些差异以及前列腺癌的发生和发展有关。在此，我们基于患者种族，在癌症基因组图谱（TCGA）数据库中分析了前列腺癌中参与雄激素代谢的基因的mRNA表达。结果显示，与美国白人前列腺癌相比，非裔美国人前列腺癌中 和 的表达较高，但 、 、 和 的表达较低。这些基因可能与前列腺癌相关的种族差异有关。然而，这一证据需要验证和功能分析。
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