Rosen David M, Kundel Vaishnavi, Rueschman Michael, Kaplan Robert, Guo Na, Wilson James G, Min Yuan-I, Redline Susan, Shah Neomi
Division of Pulmonary and Critical Care Medicine, The Valley Hospital, Ridgewood, NJ, USA.
Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1232, New York, NY, 10029, USA.
Sleep Breath. 2019 Sep;23(3):777-784. doi: 10.1007/s11325-018-01776-1. Epub 2019 Feb 13.
Evidence suggests that snoring is associated with increased risk for cardiovascular disease (CVD) events such as myocardial infarction and stroke. Limited data exists pertaining to this association among African Americans. We therefore examined the association between self-reported habitual snoring and incident CVD in the Jackson Heart Study (JHS), a population-based cohort study of African Americans.
Self-reported data on snoring and risk factors for CVD were collected at baseline (2000-2004). Participants were followed prospectively for the development of incident CVD. Habitual snoring was defined as present if the participants reported it as "often" or "almost always" or absent if reported as "sometimes," "never," or "seldom." A CVD event included stroke, myocardial infarction, coronary revascularization procedure, or fatal CHD event. Cox proportional hazards models assessed the independent association between self-reported habitual snoring and incident CVD event adjusting for multiple covariates, including age, sex, hypertension, body mass index, diabetes, hypercholesterolemia, and smoking status.
The snorer group consisted of 787 participants (mean age 52.1 years) and the nonsnorer group consisted of 3708 participants (mean age 54.9 years). Frequency of incident CVD events in the snorer group was not significantly different from the nonsnorer group. The fully adjusted hazard ratio for a CVD event in the snorer group was 1.01 (95% confidence interval [0.69, 1.47], p value of 0.96).
In conclusion, self-reported habitual snoring was not associated with incident CVD among this large African American cohort. Future studies providing objective data on snoring and sleep apnea may provide more information on the snoring-CVD association among African Americans.
Identification Number: NCT00005485.
有证据表明,打鼾与心肌梗死和中风等心血管疾病(CVD)事件风险增加有关。关于非裔美国人中这种关联的数据有限。因此,我们在杰克逊心脏研究(JHS)中调查了自我报告的习惯性打鼾与新发CVD之间的关联,JHS是一项基于人群的非裔美国人队列研究。
在基线期(2000 - 2004年)收集关于打鼾和CVD危险因素的自我报告数据。对参与者进行前瞻性随访以观察新发CVD的发生情况。如果参与者报告为“经常”或“几乎总是”打鼾,则定义为习惯性打鼾;如果报告为“有时”“从不”或“很少”,则定义为无习惯性打鼾。CVD事件包括中风、心肌梗死、冠状动脉血运重建手术或致命性冠心病事件。Cox比例风险模型评估了自我报告的习惯性打鼾与新发CVD事件之间的独立关联,并对包括年龄、性别、高血压、体重指数、糖尿病、高胆固醇血症和吸烟状况在内的多个协变量进行了调整。
打鼾者组由787名参与者(平均年龄52.1岁)组成,非打鼾者组由3708名参与者(平均年龄54.9岁)组成。打鼾者组中CVD事件的发生率与非打鼾者组无显著差异。打鼾者组发生CVD事件的完全调整后风险比为1.01(95%置信区间[0.69, 1.47],p值为0.96)。
总之,在这个大型非裔美国人队列中,自我报告的习惯性打鼾与新发CVD无关。未来提供关于打鼾和睡眠呼吸暂停客观数据的研究可能会提供更多关于非裔美国人打鼾与CVD关联的信息。
识别号:NCT00005485