Li Gaohua, Liu Hua, Ma Chunlian, Chen Yanfang, Wang Jinju, Yang Yi
School of Physical Education, Henan Agricultural University, Zhengzhou, China.
Hubei Key Laboratory of Exercise Training and Monitoring,College of Health Science, Wuhan Sports University, Wuhan, China.
J Cell Physiol. 2019 Sep;234(9):14896-14905. doi: 10.1002/jcp.28319. Epub 2019 Feb 12.
Exosomes contain regulatory signals such as lipids, proteins, and nucleic acids which can be transferred to adjacent or remote cells to mediate cell-to-cell communication. Exercise is a positive lifestyle for metabolic health and a nonpharmacological treatment of insulin resistance and metabolic diseases. Moreover, exercise is a stressor that induces cellular responses including gene expression and exosome release in various types of cells. Exosomes can carry the characters of parent cells by their modified cargoes, representing novel mechanisms for the effects of exercise. Here, we present a review of exosomes as the perspective players in mediating exercise's beneficial impacts on type 2 diabetes (T2D).
外泌体含有脂质、蛋白质和核酸等调节信号，这些信号可转移至相邻或远处的细胞，以介导细胞间通讯。运动是一种有益于代谢健康的积极生活方式，也是治疗胰岛素抵抗和代谢性疾病的非药物方法。此外，运动是一种应激源，可诱导包括基因表达和外泌体释放在内的细胞反应，这些反应存在于各种类型的细胞中。外泌体可通过其修饰的货物携带亲本细胞的特征，这代表了运动效应的新机制。在此，我们对外泌体进行综述，其作为介导运动对2型糖尿病（T2D）有益影响的关键参与者。
