Institute for Department of Cardiovascular Surgery & Cardiovascular Science, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, People's Republic of China.
Adv Exp Med Biol. 2017;1000:333-353. doi: 10.1007/978-981-10-4304-8_18.
It is known that moderate exercise can prevent the development of cardiovascular diseases, but the exact molecular mechanisms mediating cardioprotective effect of exercise remain unknown. Emerging evidence suggests that exercise has great impact on the biogenesis of exosomes, which have been found in both interstitial fluid and circulation, and play important roles in cellular communication. Exosomes carry functional molecules such as mRNAs, microRNA, and specific proteins, which can be used in the early diagnosis and targeted therapy of a variety of diseases. Our review focus on the current knowledge on exosome production, secretion, uptake and how exercise influence exosome content. We also highlight recent research development in exosome based approach for cardiac repair.
众所周知，适度运动可以预防心血管疾病的发生，但运动对心血管的保护作用的确切分子机制尚不清楚。新出现的证据表明，运动对 exosomes 的生物发生有很大的影响，exosomes 存在于细胞间隙液和血液循环中，在细胞通讯中发挥着重要作用。exosomes 携带功能性分子，如 mRNAs、microRNA 和特定蛋白质，可用于多种疾病的早期诊断和靶向治疗。我们的综述重点介绍了 exosome 产生、分泌、摄取的最新知识，以及运动如何影响 exosome 的内容。我们还强调了基于 exosome 的心脏修复方法的最新研究进展。
