Komáromy L, Tigyi A
Department of Biology, University Medical School, Pécs, Hungary.
Acta Biol Hung. 1988;39(1):17-29.
The non-ciliated bronchiolar epithelial cells (the Clara cells) are found most frequently in the distal conducting airways, but they are found throughout the tracheobronchial tree of different mammalian species. According to recent data, the main functions of the Clara cells can summarized as (1), the secretion of certain components of the extracellular bronchiolar lining layer (2), metabolism and detoxification of xenobiotics and other toxic compound (3) and participation in the renewal process of the bronchiolar epithelium. The main goal of this paper is to collect and discuss some of the general features of Clara cells from a functional-morphological point of view, and their possible role in pathological alterations of the lung especially in the pathogenesis of lung tumours originated from Clara cells.
无纤毛细支气管上皮细胞（克拉拉细胞）最常见于远端传导气道，但在不同哺乳动物物种的整个气管支气管树中都能找到。根据最新数据，克拉拉细胞的主要功能可概括为：（1）分泌细支气管内衬层细胞外某些成分；（2）对外源生物和其他有毒化合物进行代谢和解毒；（3）参与细支气管上皮的更新过程。本文的主要目的是从功能形态学角度收集和讨论克拉拉细胞的一些一般特征，以及它们在肺部病理改变尤其是源自克拉拉细胞的肺肿瘤发病机制中可能发挥的作用。
