1 Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
2 Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Exp Biol Med (Maywood). 2019 Apr;244(5):380-388. doi: 10.1177/1535370219831437. Epub 2019 Feb 13.
Neuropeptide Y (NPY) has been reported as a vasoconstrictive substance which might be associated with preeclampsia. The novel findings of this study were that Y1R, Y2R, and Y5R expressions were significantly lower in the PE than the NP group. Moreover, the NPY receptor expression ratio between the PE/NP groups was lowest for Y2R (0.27) compared to Y1R (0.42) and Y5R (0.40) suggestive of a reduction of this receptor in the preeclampsia group. Our results suggested that decreased Y2R mRNA in the PE group might be associated with abnormalities of placental angiogenesis which probably contributes to the pathophysiology of preeclampsia.
神经肽 Y（NPY）已被报道为一种血管收缩物质，可能与子痫前期有关。本研究的新发现是，Y1R、Y2R 和 Y5R 的表达在 PE 组中明显低于 NP 组。此外，PE/NP 组中 NPY 受体表达比值以 Y2R（0.27）最低，Y1R（0.42）和 Y5R（0.40），提示该受体在子痫前期组中减少。我们的结果表明，PE 组中 Y2R mRNA 的减少可能与胎盘血管生成异常有关，这可能有助于子痫前期的病理生理学。
