Department of Endocrinology, Baoding NO. 1 Central Hospital, Baoding, Hebei, China.
J Int Med Res. 2020 May;48(5):300060520919580. doi: 10.1177/0300060520919580.
To investigate the features of neuropeptide Y (NPY), α-melanocyte stimulating hormone (α-MSH), and agouti-related protein (AgRP) in type 2 diabetes mellitus (T2DM) patients with hypertension.
Patients with T2DM (n = 384) and healthy volunteers (n = 80) were enrolled into this study. Serum NPY, α-MSH, and AgRP levels were detected using ELISA.
Significantly higher NPY and lower α-MSH and AgRP levels were observed in patients with diabetes compared with those without diabetes, and the mean NPY levels increased, while α-MSH and AgRP levels decreased, with the development of hypertension compared with diabetic patients without hypertension. α-MSH and AgRP levels decreased with an increase in blood pressure in hypertension compared with the non-hypertension patients. Multiple stepwise linear regression analysis showed that NPY, α-MSH, and AgRP levels were closely associated with blood pressure and glucose control. Receiver operating characteristic (ROC) curve analyses indicated that α-MSH may be a better marker compared with NPY and AgRP for regulating glucose and blood pressure and to distinguish between T2DM patients with and without hypertension.
NPY, α-MSH, and AgRP might play different roles and be closely related to the occurrence and development of diabetes and hypertension.
探讨神经肽 Y（NPY）、α-黑素细胞刺激素（α-MSH）和刺鼠相关蛋白（AgRP）在 2 型糖尿病伴高血压患者中的特征。
纳入了 384 例 2 型糖尿病患者和 80 例健康志愿者，采用 ELISA 法检测血清 NPY、α-MSH 和 AgRP 水平。
与无糖尿病患者相比，糖尿病患者的 NPY 水平显著升高，α-MSH 和 AgRP 水平显著降低，且随着高血压的发生，NPY 水平逐渐升高，α-MSH 和 AgRP 水平逐渐降低。与非高血压患者相比，高血压患者的 α-MSH 和 AgRP 水平随着血压的升高而降低。多元逐步线性回归分析显示，NPY、α-MSH 和 AgRP 水平与血压和血糖控制密切相关。受试者工作特征（ROC）曲线分析表明，α-MSH 可能是调节血糖和血压以及区分 2 型糖尿病伴或不伴高血压患者的更好标志物，优于 NPY 和 AgRP。
NPY、α-MSH 和 AgRP 可能在糖尿病和高血压的发生和发展中发挥不同的作用，并密切相关。
