Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13th Hangkong Road, Wuhan, 430030, Hubei, China.
BMC Infect Dis. 2019 Feb 13;19(1):147. doi: 10.1186/s12879-019-3749-1.
The relationship between chronic hepatitis B virus (HBV) infection with gestational diabetes mellitus (GDM) remains unclear. This study aimed to identify the association between maternal HBsAg-positive status and GDM.
A retrospective cohort study was performed on the pregnant women who delivered from June 2012 to May 2016 at Wuhan Medical Care Center for Women and Children, Wuhan, China. We compared the incidence of GDM between HBsAg-positive pregnant women and HBsAg-negative controls. A multivariate regression model was used to measure the independent association between maternal HBsAg carrier and the risk of developing GDM.
In total, 964 HBsAg-positive pregnant women and 964 HBsAg-negative women were included into the study. We observed maternal HBsAg carrier (OR 1.47, 95% CI 1.06-2.03), age (OR 1.05, 95% CI 1.00-1.10) and family history of diabetes (OR 3.97, 95% CI 2.05-7.67) had an independent risk for GDM in multivariable logistical regression model. However, no significant association was found between HBeAg carrier status, other HBV markers or viral load in pregnancy and the incidence of GDM.
Our results indicated that maternal HBsAg carriage is an independent risk factor for GDM, but viral activity indicated by HBeAg status and viral load is not the main reason for this phenomenon. Further studies are warranted to clarify the possible mechanisms behind such association of HBV infection and the additional risk of GDM.
慢性乙型肝炎病毒（HBV）感染与妊娠糖尿病（GDM）之间的关系尚不清楚。本研究旨在确定母体 HBsAg 阳性状态与 GDM 之间的关联。
采用回顾性队列研究，对 2012 年 6 月至 2016 年 5 月在武汉医疗保健中心妇产科分娩的孕妇进行研究。我们比较了 HBsAg 阳性孕妇和 HBsAg 阴性对照组 GDM 的发生率。采用多变量回归模型来衡量母体 HBsAg 携带者与发生 GDM 风险之间的独立关联。
共纳入 964 例 HBsAg 阳性孕妇和 964 例 HBsAg 阴性孕妇。我们观察到母体 HBsAg 携带（OR 1.47，95%CI 1.06-2.03）、年龄（OR 1.05，95%CI 1.00-1.10）和糖尿病家族史（OR 3.97，95%CI 2.05-7.67）是多变量逻辑回归模型中 GDM 的独立危险因素。然而，在妊娠期间 HBeAg 携带状态、其他 HBV 标志物或病毒载量与 GDM 的发生率之间未发现显著关联。
我们的结果表明，母体 HBsAg 携带是 GDM 的独立危险因素，但 HBeAg 状态和病毒载量所指示的病毒活性不是造成这种现象的主要原因。需要进一步的研究来阐明 HBV 感染与 GDM 风险增加之间的可能机制。
