Sirilert Sirinart, Traisrisilp Kuntharee, Sirivatanapa Pannee, Tongsong Theera
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Int J Gynaecol Obstet. 2014 Aug;126(2):106-10. doi: 10.1016/j.ijgo.2014.02.019. Epub 2014 Apr 24.
To compare pregnancy outcomes of women with chronic HBV infection with those of HBV-negative women.
A retrospective cohort study was undertaken to analyze singleton pregnancies of women without medical/surgical disease and with known HBsAg status. Pregnancy outcome measures were compared among the control group, women with positive HBsAg status (case group), and those with positive HBeAg status.
Among 26 350 enrolled pregnant women, 21 812 in the control group and 1446 in the case group were compared. Only the proportion of preterm births was significantly higher among pregnancies with positive HBsAg status (RR 1.013 [95% CI, 1.001-1.025]). Among women with positive HBsAg status who had been screened for HBeAg, GDM was significantly higher among women with positive HBeAg status (RR 1.434 [95% CI, 0.999-2.057]). Preterm births and low birth weight were also significantly higher among women with positive HBeAg status (RR 1.250 [95% CI, 1.000-1.563] and 1.258 [95% CI, 1.053-1.505], respectively).
Chronic carriers of HBV had a minimally increased risk of preterm birth and low birth weight but the risk was more pronounced in women with positive HBeAg status. Women with positive HBeAg status also had an increased risk of GDM.
比较慢性乙肝病毒（HBV）感染女性与HBV阴性女性的妊娠结局。
开展一项回顾性队列研究，分析无内科/外科疾病且已知HBsAg状态女性的单胎妊娠情况。比较对照组、HBsAg状态阳性女性（病例组）和HBeAg状态阳性女性的妊娠结局指标。
在26350名登记的孕妇中，比较了对照组的21812名孕妇和病例组的1446名孕妇。仅HBsAg状态阳性的妊娠中早产比例显著更高（相对危险度1.013[95%可信区间，1.001 - 1.025]）。在已筛查HBeAg的HBsAg状态阳性女性中，HBeAg状态阳性女性的妊娠期糖尿病（GDM）显著更高（相对危险度1.434[95%可信区间，0.999 - 2.057]）。HBeAg状态阳性女性的早产和低出生体重也显著更高（相对危险度分别为1.250[95%可信区间，1.000 - 1.563]和1.258[95%可信区间，1.053 - 1.505]）。
HBV慢性携带者早产和低出生体重风险略有增加，但在HBeAg状态阳性女性中风险更明显。HBeAg状态阳性女性患GDM的风险也增加。
