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拟南芥端粒染色质的表观遗传学方面。

Epigenetic aspects of telomeric chromatin in Arabidopsis thaliana.

机构信息

Department of Systems Biology, Yonsei University, Seoul 03722, Korea.

出版信息

BMB Rep. 2019 Mar;52(3):175-180. doi: 10.5483/BMBRep.2019.52.3.047.

Abstract

Telomeres are nucleoprotein complexes at the physical ends of linear eukaryotic chromosomes. They protect the chromosome ends from various external attacks to avoid the loss of genetic information. Telomeres are maintained by cellular activities associated with telomerase and telomerebinding proteins. In addition, epigenetic regulators have pivotal roles in controlling the chromatin state at the telomeres and the subtelomeric regions, contributing to the maintenance of chromosomal homeostasis in yeast, animals, and plants. Here, we review the recent findings on chromatin modifications possibly associated with the dynamic states of telomeres in Arabidopsis thaliana. [BMB Reports 2019; 52(3): 175-180].

摘要

端粒是线性真核染色体物理末端的核蛋白复合物。它们保护染色体末端免受各种外部攻击,以避免遗传信息的丢失。端粒由与端粒酶和端粒结合蛋白相关的细胞活动维持。此外,表观遗传调节剂在控制端粒和亚端粒区域的染色质状态方面发挥着关键作用,有助于维持酵母、动物和植物中的染色体动态平衡。在这里,我们综述了最近关于拟南芥中端粒动态状态相关的染色质修饰的发现。[BMB 报告 2019;52(3):175-180]。

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本文引用的文献

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DDM1 guards against telomere truncation in Arabidopsis.DDM1 可防止拟南芥端粒缩短。
Plant Cell Rep. 2018 Mar;37(3):501-513. doi: 10.1007/s00299-017-2245-6. Epub 2018 Feb 1.
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Epigenetic features of human telomeres.人类端粒的表观遗传特征。
Nucleic Acids Res. 2018 Mar 16;46(5):2347-2355. doi: 10.1093/nar/gky006.
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Sirtuins in epigenetic regulation.表观遗传调控中的沉默调节蛋白
Chem Rev. 2015 Mar 25;115(6):2350-75. doi: 10.1021/cr500457h. Epub 2015 Jan 28.
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Assembly of telomeric chromatin to create ALTernative endings.端粒染色质的组装,以产生端粒酶的非经典端粒末端。
Trends Cell Biol. 2014 Nov;24(11):675-85. doi: 10.1016/j.tcb.2014.07.007. Epub 2014 Aug 26.
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Biology of telomeres: lessons from budding yeast.端粒生物学:芽殖酵母的启示。
FEMS Microbiol Rev. 2014 Mar;38(2):144-71. doi: 10.1111/1574-6976.12054.

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