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Sirtuins in epigenetic regulation.

作者信息

Jing Hui, Lin Hening

机构信息

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14850, United States.

出版信息

Chem Rev. 2015 Mar 25;115(6):2350-75. doi: 10.1021/cr500457h. Epub 2015 Jan 28.

DOI:10.1021/cr500457h
PMID:25804908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4610301/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d6a/4610301/86895f8b55bd/cr-2014-00457h_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d6a/4610301/e52d5cd3ee96/cr-2014-00457h_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d6a/4610301/084186ea9a74/cr-2014-00457h_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d6a/4610301/86895f8b55bd/cr-2014-00457h_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d6a/4610301/e52d5cd3ee96/cr-2014-00457h_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d6a/4610301/084186ea9a74/cr-2014-00457h_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d6a/4610301/86895f8b55bd/cr-2014-00457h_0003.jpg

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Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.SIRT6对昼夜节律转录进行分区，从而实现对细胞代谢的分离控制。
Cell. 2014 Jul 31;158(3):659-72. doi: 10.1016/j.cell.2014.06.050.
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MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.由AKT1磷酸化的SIRT6经MDM2介导的降解促进乳腺癌的肿瘤发生和曲妥珠单抗耐药。
Sci Signal. 2014 Jul 29;7(336):ra71. doi: 10.1126/scisignal.2005076.
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Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.
Results Probl Cell Differ. 2025;75:25-69. doi: 10.1007/978-3-031-91459-1_2.
4
Structural and enzymatic plasticity of SIRT6 deacylase activity.SIRT6去乙酰化酶活性的结构与酶促可塑性。
J Biol Chem. 2025 Mar 25;301(5):108446. doi: 10.1016/j.jbc.2025.108446.
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Structural basis of SIRT7 nucleosome engagement and substrate specificity.SIRT7与核小体结合及底物特异性的结构基础。
Nat Commun. 2025 Feb 4;16(1):1328. doi: 10.1038/s41467-025-56529-y.
6
Ribose-induced advanced glycation end products reduce the lifespan in Drosophila melanogaster by changing the redox state and down-regulating the Sirtuin genes.核糖诱导的晚期糖基化终产物通过改变氧化还原状态和下调沉默调节蛋白基因来缩短黑腹果蝇的寿命。
Biogerontology. 2024 Dec 19;26(1):28. doi: 10.1007/s10522-024-10172-0.
7
Crosstalk between metabolic and epigenetic modifications during cell carcinogenesis.细胞癌变过程中代谢与表观遗传修饰之间的相互作用。
iScience. 2024 Nov 15;27(12):111359. doi: 10.1016/j.isci.2024.111359. eCollection 2024 Dec 20.
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The Mechanistic Link Between Tau-Driven Proteotoxic Stress and Cellular Senescence in Alzheimer's Disease.tau 驱动的蛋白毒性应激与阿尔茨海默病中细胞衰老的机制联系。
Int J Mol Sci. 2024 Nov 17;25(22):12335. doi: 10.3390/ijms252212335.
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Prog Retin Eye Res. 2025 Jan;104:101318. doi: 10.1016/j.preteyeres.2024.101318. Epub 2024 Nov 14.
10
Maternal exercise represses FGF21 via SIRT1 to improve the phenotypic transformation of vascular smooth muscle in hypertensive offspring.母体运动通过SIRT1抑制FGF21，以改善高血压子代血管平滑肌的表型转化。
Hypertens Res. 2025 Jan;48(1):353-365. doi: 10.1038/s41440-024-01991-2. Epub 2024 Nov 14.
肿瘤抑制因子 p53 通过促进 FoxO1 核输出与 SIRT6 合作调节糖异生。
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PLoS One. 2014 May 29;9(5):e98438. doi: 10.1371/journal.pone.0098438. eCollection 2014.
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PLoS One. 2014 May 23;9(5):e97999. doi: 10.1371/journal.pone.0097999. eCollection 2014.
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SIRT2 as a new player in epigenetic programming of keratinocyte differentiation and a candidate tumor suppressor.SIRT2作为角质形成细胞分化表观遗传编程中的新角色及候选肿瘤抑制因子。
Exp Dermatol. 2014 Sep;23(9):636-8. doi: 10.1111/exd.12434.
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ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation.血管紧张素II通过激活JNK和降解SIRT1抑制热休克因子1，从而促进胰岛素样生长因子-II受体表达和心肌细胞凋亡。
Cell Death Differ. 2014 Aug;21(8):1262-74. doi: 10.1038/cdd.2014.46. Epub 2014 May 2.
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Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase.氧化应激激活 SIRT2 去乙酰化并刺激磷酸甘油酸变位酶。
Cancer Res. 2014 Jul 1;74(13):3630-42. doi: 10.1158/0008-5472.CAN-13-3615. Epub 2014 May 1.