Cardiology Clinic, Acıbadem Ankara Hospital, Acıbadem University, Ankara, Turkey.
Med Sci Monit. 2019 Feb 14;25:1194-1203. doi: 10.12659/MSM.913561.
BACKGROUND The myocardial performance index (MPI) is a comprehensive measure of global systolic and diastolic function of the ventricle, and it has an inverse correlation with maximal oxygen consumption. In this study, the potential association between left ventricle MPI and biochemical biomarkers (including iron, homocysteine, and lipids) in elite athletes was investigated. MATERIAL AND METHODS This cross-sectional observational study consisted of 80 young male elite soccer and basketball players (age: 18-34 years) examined for a seasonal medical check-up. Cardiological examinations and transthoracic echocardiography of these athletes were performed and blood samples were analyzed according to standard laboratory protocols. Tissue Doppler recording was acquired from the mitral annulus using apical 4-chamber view and then the tissue Doppler-derived MPI was computed. RESULTS Athletes were separated into 2 groups based on MPI values (MPI ≤0.40 and MPI >0.40), and baseline demographic, clinical, and biochemical variables of the study participants were compared between these 2 groups. Serum triglyceride, high-density lipoprotein, total cholesterol, homocysteine levels, and iron parameters did not significantly differ between groups, while low-density lipoprotein level was significantly lower in the MPI ≤0.40 group (103.8±26.0 mg/dl vs. 116.8±30.2 mg/dl; p=0.043). Correlation analysis and multivariate linear regression analysis demonstrated a significant association between low-density lipoprotein and MPI. CONCLUSIONS In this study, various biochemical markers were evaluated for possible association with left ventricle MPI as a surrogate of cardiac performance. Among these biomarkers, only low-density lipoprotein was significantly associated with MPI in elite athletes.
心肌做功指数（MPI）是一种综合评估心室收缩和舒张功能的指标，与最大耗氧量呈反比。本研究旨在探讨左心室 MPI 与精英运动员生化标志物（包括铁、同型半胱氨酸和脂质）之间的潜在相关性。
本横断面观察性研究纳入了 80 名年轻男性精英足球和篮球运动员（年龄 18-34 岁），进行季节性体检。对这些运动员进行了心脏检查和经胸超声心动图检查，并按照标准实验室方案分析了血液样本。使用心尖四腔心切面获取二尖瓣环的组织多普勒记录，然后计算组织多普勒衍生的 MPI。
根据 MPI 值将运动员分为两组（MPI≤0.40 和 MPI>0.40），并比较两组之间研究参与者的基线人口统计学、临床和生化变量。两组间血清三酰甘油、高密度脂蛋白、总胆固醇、同型半胱氨酸水平和铁参数无显著差异，而 MPI≤0.40 组的低密度脂蛋白水平显著较低（103.8±26.0 mg/dl 比 116.8±30.2 mg/dl；p=0.043）。相关性分析和多元线性回归分析表明，低密度脂蛋白与 MPI 之间存在显著相关性。
在这项研究中，评估了各种生化标志物与左心室 MPI 作为心脏功能的替代指标之间的可能相关性。在这些生物标志物中，只有低密度脂蛋白与精英运动员的 MPI 显著相关。
