生酮饮食与癫痫：目前我们所了解的情况。
Ketogenic Diet and Epilepsy: What We Know So Far.
作者信息
D'Andrea Meira Isabella, Romão Tayla Taynan, Pires do Prado Henrique Jannuzzelli, Krüger Lia Theophilo, Pires Maria Elisa Paiva, da Conceição Priscila Oliveira
机构信息
Epilepsy Department, Paulo Niemeyer State Brain Institute, Rio de Janeiro, Brazil.
Neurology Department, Federal Fluminense University, Rio de Janeiro, Brazil.
出版信息
Front Neurosci. 2019 Jan 29;13:5. doi: 10.3389/fnins.2019.00005. eCollection 2019.
The Ketogenic Diet (KD) is a modality of treatment used since the 1920s as a treatment for intractable epilepsy. It has been proposed as a dietary treatment that would produce similar benefits to fasting, which is already recorded in the Hippocratic collection. The KD has a high fat content (90%) and low protein and carbohydrate. Evidence shows that KD and its variants are a good alternative for non-surgical pharmacoresistant patients with epilepsy of any age, taking into account that the type of diet should be designed individually and that less-restrictive and more-palatable diets are usually better options for adults and adolescents. This review discusses the KD, including the possible mechanisms of action, applicability, side effects, and evidence for its efficacy, and for the more-palatable diets such as the Modified Atkins Diet (MAD) and the Low Glycemic Index Diet (LGID) in children and adults.
生酮饮食（KD）自20世纪20年代起就被用作治疗难治性癫痫的一种治疗方式。它被提议作为一种饮食疗法，其产生的益处与禁食相似，这在希波克拉底文集中已有记载。生酮饮食脂肪含量高（90%），蛋白质和碳水化合物含量低。有证据表明，考虑到饮食类型应个体化设计，且限制较少、更可口的饮食通常对成人和青少年是更好的选择，生酮饮食及其变体对于任何年龄的非手术药物抵抗性癫痫患者都是一个不错的选择。本综述讨论了生酮饮食，包括其可能的作用机制、适用性、副作用以及其疗效的证据，还讨论了儿童和成人中更可口的饮食，如改良阿特金斯饮食（MAD）和低血糖指数饮食（LGID）。
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