State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Immunol. 2019 Jan 29;10:62. doi: 10.3389/fimmu.2019.00062. eCollection 2019.
Type 2 immunity participates in the pathogeneses of helminth infection and allergic diseases. Emerging evidence indicates that the components of type 2 immunity are also involved in maintaining metabolic hemostasis and facilitating the healing process after tissue injury. Numerous preclinical studies have suggested regulation of type 2 immunity-related cytokines, such as interleukin-4, -13, and -33, and cell types, such as M2 macrophages, mast cells, and eosinophils, affects cardiac functions after myocardial infarction (MI), providing new insights into the importance of immune modulation in the infarcted heart. This review provides an overview of the functions of these cytokines and cells in the setting of MI as well as their potential to predict the severity and prognosis of MI.
2 型免疫参与寄生虫感染和过敏性疾病的发病机制。新出现的证据表明，2 型免疫的成分也参与维持代谢止血和促进组织损伤后的愈合过程。大量的临床前研究表明，调节 2 型免疫相关细胞因子，如白细胞介素-4、-13 和-33，以及细胞类型，如 M2 巨噬细胞、肥大细胞和嗜酸性粒细胞，可影响心肌梗死后的心脏功能，为免疫调节在梗死心脏中的重要性提供了新的见解。这篇综述概述了这些细胞因子和细胞在心肌梗死后的作用及其预测心肌梗死严重程度和预后的潜力。
Zotero 插件
