Department of Clinical Research Center, Xuyi People's Hospital, 28 hongwu Road, Xuyi, Jiangsu, 211700, People's Republic of China.
Pathol Oncol Res. 2019 Oct;25(4):1295-1301. doi: 10.1007/s12253-019-00612-5. Epub 2019 Feb 13.
Suppressor of cytokine signaling1 (SOCS1), as a member of SOCS family, has been widely studied in recent years. It has been found that SOCS1 not only participates in cell signaling, but also in ubiquitination mediated protein degradation process. Both of these two functions play an important role in the growth and proliferation of cells. Therefore, researchers speculated that SOCS1 also played an important role in tumors. This review mainly focuses on the structure, transcriptional regulation and functions of SOCS1 protein, and finally describes the possible clinical role of SOCS1 protein in tumors.
抑制细胞因子信号转导 1（SOCS1）作为 SOCS 家族的一员，近年来受到广泛研究。研究发现，SOCS1 不仅参与细胞信号转导，还参与泛素化介导的蛋白降解过程。这两个功能都在细胞的生长和增殖中起着重要作用。因此，研究人员推测 SOCS1 在肿瘤中也起着重要作用。本综述主要集中于 SOCS1 蛋白的结构、转录调控和功能，并最后描述 SOCS1 蛋白在肿瘤中的可能临床作用。
