Marine Biology Institute, Shantou University, Shantou, Guangdong, 515063, People's Republic of China.
State Key Laboratory in Marine Pollution, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China.
Environ Sci Pollut Res Int. 2019 Apr;26(10):10306-10318. doi: 10.1007/s11356-019-04201-6. Epub 2019 Feb 13.
Benzotriazole and its associated derivatives (BTs) are widely used as ultraviolet stabilizers and corrosion inhibitors. They have been extensively found in marine environments and are bioaccumulative through the food chain. However, the toxicities of BTs to marine organisms are seldom identified and no assessment has been conducted for filter-feeding bivalves. In this study, a marine scallop Chlamys nobilis was exposed to 0, 0.01, 0.1, and 1.0 mg/L of BT for 60 days. Effects of BT on endocrine system, cytochrome P450 activity, antioxidant activity, and neural activity of C. nobilis were examined. The results showed that BT exerted significant estrogenic effects on both male and female scallops and inhibited EROD activities of C. nobilis even at 0.01 mg/L level. BT at ≥ 0.01 mg/L levels also caused significant oxidative stress on C. nobilis. Moreover, most of the adverse effects of BT to C. nobilis were found from day 35 and 0.01 mg/L was the lowest concentration with observed effects, showing the long-term toxic effects of BT to C. nobilis. Thus, the adverse effects of BT and its derivatives to marine benthic communities deserve more attention in future research.
苯并三唑及其相关衍生物（BTs）被广泛用作紫外线稳定剂和腐蚀抑制剂。它们在海洋环境中广泛存在，并通过食物链进行生物累积。然而，BTs 对海洋生物的毒性很少被确定，也没有对滤食性双壳贝类进行评估。在这项研究中，海洋扇贝 Chlamys nobilis 暴露于 0、0.01、0.1 和 1.0 mg/L 的 BT 中 60 天。研究了 BT 对 C. nobilis 内分泌系统、细胞色素 P450 活性、抗氧化活性和神经活性的影响。结果表明，BT 对雄性和雌性扇贝均表现出显著的雌激素效应，即使在 0.01 mg/L 水平也能抑制 C. nobilis 的 EROD 活性。BT 浓度≥0.01 mg/L 也会对 C. nobilis 造成显著的氧化应激。此外，BT 对 C. nobilis 的大多数不良影响在第 35 天就出现了，而 0.01 mg/L 是观察到效果的最低浓度，这表明 BT 对 C. nobilis 的长期毒性作用。因此，BT 及其衍生物对海洋底栖生物群落的不良影响在未来的研究中值得更多关注。
