Section on the Neurobiology and Treatment of Mood Disorders, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Division of Child/Adolescent Psychiatry, PediMIND Program, Bradley Hospital, Brown University School of Medicine, East Providence, RI, USA.
Suicide Life Threat Behav. 2019 Dec;49(6):1600-1608. doi: 10.1111/sltb.12543. Epub 2019 Feb 13.
A critical need exists to identify objective markers of suicide ideation. One potential suicide risk marker is the Suicide Implicit Association Task (S-IAT), a behavioral task that uses differential reaction times to compare the implicit association between the self and death to the implicit association between the self and life. Individuals with a stronger association between the self and death on the S-IAT are more likely to attempt suicide in the future. To better understand the neural underpinnings of the implicit association between self and either life or death, a functional magnetic resonance imaging (fMRI) version of the S-IAT was adapted and piloted in healthy volunteers.
An fMRI version of the S-IAT was administered to 28 healthy volunteers (ages 18-65, 14F/14M).
Behavioral results were comparable to those seen in non-scanner versions of the task. The task was associated with patterns of neural activation in areas relevant to emotional processing, specifically the insula and right ventrolateral prefrontal cortex.
Performance on the S-IAT fMRI task may reflect scores obtained outside of the scanner. In future evaluations, this task could help assess whether individuals at increased risk of suicide display a different pattern of neural activation in response to self/death and self/life stimuli.
确定自杀意念的客观标志物是当务之急。自杀意念的一个潜在风险标志物是自杀内隐联想测验（S-IAT），这是一种行为任务，它使用不同的反应时间来比较自我与死亡之间的内隐联想与自我与生命之间的内隐联想。在 S-IAT 中，自我与死亡之间的关联越强的个体，未来自杀的可能性就越大。为了更好地理解自我与生命或死亡之间的内隐联想的神经基础，我们改编并在健康志愿者中试用了 S-IAT 的功能磁共振成像（fMRI）版本。
对 28 名健康志愿者（年龄 18-65 岁，14 名女性/14 名男性）进行了 S-IAT 的 fMRI 测试。
行为结果与非扫描版本任务中的结果相似。该任务与与情绪处理相关的区域（特别是岛叶和右侧腹外侧前额叶皮质）的神经激活模式有关。
在 fMRI 任务中 S-IAT 的表现可能反映了在扫描仪外获得的分数。在未来的评估中，这项任务可以帮助评估自杀风险增加的个体在对自我/死亡和自我/生命刺激的反应中是否表现出不同的神经激活模式。
