Kuzmenko A V, Kuzmenko V V, Gyaurgiev T A
Department of Urology, N.N. Burdenko Voronezh State Medical University, Voronezh, Russia.
Urologiia. 2018 Oct(4):10-13.
Lower urinary tract infections (LUTI) are the most common urological diseases. Fosfomycin is one of the antibiotic agents with proven efficacy that are most frequently used to treat UTIs. Despite the high effectiveness of antibiotic therapy with this drug, in some patients, the LUTIs persist or recur. It is advisable to prevent the development of recurrent infections using herbal preparations. The study aimed to evaluate the effectiveness of integrated treatment of women with acute uncomplicated cystitis using the plant-based medication Phytolysin.
The study comprised 63 women with acute uncomplicated cystitis, who were randomly assigned to two groups. The women in the control group (n = 31) received a single 3-g dose of fosfomycin. In the study group (n = 32), women received a single 3-g dose of fosfomycin and Phytolysin according to the manufacturers instructions three times daily for a month. The examination was performed on admission and on days 3, and 7, and included daily filling out voiding diaries, a 5-point verbal assessment of pain, urinalysis and urine culture. During the next three months, cases of recurrence were registered, and bacteriological analysis of urine was conducted.
On admission, all patients complained of pain in the projection of the urinary bladder, frequent urination in small portions, and a sensation of urethral discomfort. All women had leukocyturia and bacteriuria. By the 3-rd day after taking fosfomycin, both groups showed similar improvement in the clinical manifestations of the disease. All urine cultures were negative. By the 7th day after the initiation of therapy, the patients in the study group had normal laboratory parameters and no clinical manifestation of LUTI, while in the control group leukocyturia (p <0.05) persisted. During a 3-month follow-up, recurrence of LUTI was observed in 6 (19.4%) and 3 (9.4%) patients in the control and study group, respectively. Also, bacteriological studies of urine showed the same pathogen as on admission in 5 (16.1%) and 1 (3.2%) patients of the control and study group, respectively.
Phytolysin can be recommended for use in the integrated management of acute uncomplicated cystitis, as well as a means of preventing recurrences of this disease.
下尿路感染（LUTI）是最常见的泌尿系统疾病。磷霉素是治疗尿路感染最常用且已证实有效的抗生素之一。尽管使用这种药物进行抗生素治疗效果显著，但在一些患者中，下尿路感染仍持续存在或复发。使用草药制剂预防复发性感染是可取的。本研究旨在评估使用植物性药物Phytolysin综合治疗急性单纯性膀胱炎女性患者的有效性。
本研究纳入63例急性单纯性膀胱炎女性患者，随机分为两组。对照组（n = 31）的女性接受单次3克剂量的磷霉素治疗。研究组（n = 32）的女性接受单次3克剂量的磷霉素，并按照制造商说明每日三次服用Phytolysin，持续一个月。入院时、第3天和第7天进行检查，包括每日填写排尿日记、对疼痛进行5分制口头评估、尿液分析和尿培养。在接下来的三个月里，记录复发病例，并进行尿液细菌学分析。
入院时，所有患者均主诉膀胱区疼痛、少量多次尿频以及尿道不适感。所有女性均有白细胞尿和菌尿。服用磷霉素后第3天，两组疾病临床表现的改善情况相似。所有尿培养均为阴性。治疗开始后第7天，研究组患者实验室参数正常，无下尿路感染的临床表现，而对照组白细胞尿持续存在（p <0.05）。在3个月的随访期间，对照组和研究组分别有6例（19.4%）和3例（9.4%）患者出现下尿路感染复发。此外，对照组和研究组分别有5例（16.1%）和1例（3.2%）患者尿液细菌学研究显示与入院时为同一病原体。
Phytolysin可推荐用于急性单纯性膀胱炎的综合管理，以及预防该疾病的复发。
