土耳其免疫抑制患者中粪类圆线虫血清流行率的调查。
The investigation of Strongyloides stercoralis seroprevalence in immunosupressed patients in Turkey.
出版信息
Turk J Med Sci. 2019 Feb 11;49(1):16-19. doi: 10.3906/sag-1804-16.
BACKGROUND/AIM: In immunosuppressed patients, strongyloidiasis can be lifethreatening because of hyperinfection or dissemination. Therefore, diagnosis of S. stercoralis is important in immunosuppressed patients with chronic strongyloidiasis. In this study, our objective was to investigate the presence of S. stercoralis antibodies by an ELISA method in immunosuppressed patients.
MATERIALS AND METHODS
A total of 100 immunosuppressed patients’ sera were included in the study. Forty-two of the patients were receiving immunosuppressive therapies for cancer or being treated for hematopoietic malignancies, 38 of the patients were receiving immunosuppressive drugs for rheumatic diseases, 14 were receiving immunosuppressive therapies for liver transplantation. Two of the patients were being treated for HIV infection and 4 were being treated for hypogammaglobulinemia. As control group, 50 individuals without a known disease were included in the study. The presence of IgG antibodies against S. stercoralis was investigated with a commercial ELISA kit.
RESULTS
S. stercoralis antibody test was positive in 4 of 100 (4%) sera from immunosuppressed patients. All control patients were negative for S. stercoralis.
CONCLUSIONS
Strongyloidiasis can be a lifelong chronic infection if not treated. In patients who are going to receive immunosuppressive therapy, it should be tested before treatment, as it can become a disseminated and life-threatening infectious disease.
背景/目的：在免疫抑制患者中，由于过度感染或播散，类圆线虫病可能危及生命。因此，对于患有慢性类圆线虫病的免疫抑制患者，诊断 S. stercoralis 非常重要。在这项研究中，我们的目的是通过 ELISA 方法调查免疫抑制患者中是否存在 S. stercoralis 抗体。
材料和方法
共纳入 100 例免疫抑制患者的血清。42 例患者因癌症接受免疫抑制治疗或因血液恶性肿瘤接受治疗，38 例患者因风湿性疾病接受免疫抑制药物治疗，14 例因肝移植接受免疫抑制治疗。2 例患者因 HIV 感染接受治疗，4 例因低丙种球蛋白血症接受治疗。作为对照组，纳入了 50 名无已知疾病的个体。使用商业 ELISA 试剂盒检测针对 S. stercoralis 的 IgG 抗体的存在。
结果
在 100 份免疫抑制患者血清中，有 4 份（4%）的 S. stercoralis 抗体检测呈阳性。所有对照患者的 S. stercoralis 均为阴性。
结论
如果不治疗，类圆线虫病可能成为终身慢性感染。在将要接受免疫抑制治疗的患者中，应在治疗前进行检测，因为它可能成为一种播散性和危及生命的传染病。
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