由miR126 - 5p调控的肌肉毒性因子分泌促进了肌萎缩侧索硬化症中运动神经元的退化。 - Suppr

Muscle secretion of toxic factors, regulated by miR126-5p, facilitates motor neuron degeneration in amyotrophic lateral sclerosis.

作者信息

Maimon Roy, Perlson Eran

机构信息

Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

出版信息

Neural Regen Res. 2019 Jun;14(6):969-970. doi: 10.4103/1673-5374.250571.

DOI:10.4103/1673-5374.250571

PMID:30762002

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6404484/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7139/6404484/5078be782d28/NRR-14-969-g001.jpg

相似文献

Muscle secretion of toxic factors, regulated by miR126-5p, facilitates motor neuron degeneration in amyotrophic lateral sclerosis.

Neural Regen Res. 2019 Jun;14(6):969-970. doi: 10.4103/1673-5374.250571.

miR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption via a Non-Cell-Autonomous Mechanism in ALS.

J Neurosci. 2018 Jun 13;38(24):5478-5494. doi: 10.1523/JNEUROSCI.3037-17.2018. Epub 2018 May 17.

Serum neurofilament light chain levels as a marker of upper motor neuron degeneration in patients with Amyotrophic Lateral Sclerosis.

Neuropathol Appl Neurobiol. 2019 Apr;45(3):291-304. doi: 10.1111/nan.12511. Epub 2018 Jul 18.

Amino acids for amyotrophic lateral sclerosis / motor neuron disease.

Cochrane Database Syst Rev. 2003(4):CD003457. doi: 10.1002/14651858.CD003457.

WITHDRAWN: Amino acids for amyotrophic lateral sclerosis / motor neuron disease.

Cochrane Database Syst Rev. 2008 Apr 16(2):CD003457. doi: 10.1002/14651858.CD003457.pub2.

Calcium in the pathomechanism of amyotrophic lateral sclerosis - Taking center stage?

Biochem Biophys Res Commun. 2017 Feb 19;483(4):1031-1039. doi: 10.1016/j.bbrc.2016.08.089. Epub 2016 Aug 18.

Supportive care needs of patients with amyotrophic lateral sclerosis/motor neuron disease and their caregivers: A scoping review.

J Clin Nurs. 2017 Dec;26(23-24):4129-4152. doi: 10.1111/jocn.13945. Epub 2017 Aug 31.

Mechanisms for neuronal degeneration in amyotrophic lateral sclerosis and in models of motor neuron death (Review).

Int J Mol Med. 2000 Jan;5(1):3-13. doi: 10.3892/ijmm.5.1.3.

A potential role for the p75 low-affinity neurotrophin receptor in spinal motor neuron degeneration in murine and human amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Other Motor Neuron Disord. 2001 Sep;2(3):127-34. doi: 10.1080/146608201753275463.

Why are upper motor neuron signs difficult to elicit in amyotrophic lateral sclerosis?

J Neurol Neurosurg Psychiatry. 2012 Jun;83(6):659-62. doi: 10.1136/jnnp-2012-302315. Epub 2012 Apr 11.

引用本文的文献

MiR-126 accelerates renal injury induced by UUO via inhibition PI3K/ IRS-1/ FAK signaling induced M2 polarization and endocytosis in macrophages.

Sci Rep. 2024 Oct 30;14(1):26083. doi: 10.1038/s41598-024-77691-1.

Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death.

Mol Med. 2024 Oct 25;30(1):185. doi: 10.1186/s10020-024-00942-4.

Thin-film conformal fluorescent SU8-phenylenediamine.

Nanoscale. 2023 Nov 9;15(43):17544-17554. doi: 10.1039/d3nr02744a.

The Cellular and Molecular Signature of ALS in Muscle.

J Pers Med. 2022 Nov 8;12(11):1868. doi: 10.3390/jpm12111868.

Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins.

Int J Mol Sci. 2021 Jun 6;22(11):6111. doi: 10.3390/ijms22116111.

A Human-Based Functional NMJ System for Personalized ALS Modeling and Drug Testing.

Adv Ther (Weinh). 2020 Nov;3(11). doi: 10.1002/adtp.202000133. Epub 2020 Aug 11.

本文引用的文献

Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150 Deacetylation by Axonal HDAC1.

Dev Cell. 2018 Aug 6;46(3):376-387.e7. doi: 10.1016/j.devcel.2018.07.001.

miR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption via a Non-Cell-Autonomous Mechanism in ALS.

J Neurosci. 2018 Jun 13;38(24):5478-5494. doi: 10.1523/JNEUROSCI.3037-17.2018. Epub 2018 May 17.

Spatial-specific functions in retrograde neuronal signalling.

Traffic. 2017 Jul;18(7):415-424. doi: 10.1111/tra.12487. Epub 2017 May 18.

ALS Along the Axons - Expression of Coding and Noncoding RNA Differs in Axons of ALS models.

Sci Rep. 2017 Mar 16;7:44500. doi: 10.1038/srep44500.

Expression of a Mutant SEMA3A Protein with Diminished Signalling Capacity Does Not Alter ALS-Related Motor Decline, or Confer Changes in NMJ Plasticity after BotoxA-Induced Paralysis of Male Gastrocnemic Muscle.

PLoS One. 2017 Jan 19;12(1):e0170314. doi: 10.1371/journal.pone.0170314. eCollection 2017.

The Axon Guidance Protein Semaphorin 3A Is Increased in the Motor Cortex of Patients With Amyotrophic Lateral Sclerosis.

J Neuropathol Exp Neurol. 2016 Apr;75(4):326-333. doi: 10.1093/jnen/nlw003. Epub 2016 Feb 25.

Axon guidance proteins in neurological disorders.

Lancet Neurol. 2015 May;14(5):532-46. doi: 10.1016/S1474-4422(14)70257-1. Epub 2015 Mar 11.

Semaphorin 3A signaling through neuropilin-1 is an early trigger for distal axonopathy in the SOD1G93A mouse model of amyotrophic lateral sclerosis.

J Neuropathol Exp Neurol. 2014 Jul;73(7):702-13. doi: 10.1097/NEN.0000000000000086.

Astrocyte-encoded positional cues maintain sensorimotor circuit integrity.

Nature. 2014 May 8;509(7499):189-94. doi: 10.1038/nature13161. Epub 2014 Apr 28.

Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.

Neuron. 2012 Jun 21;74(6):1031-44. doi: 10.1016/j.neuron.2012.05.009.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Muscle secretion of toxic factors, regulated by miR126-5p, facilitates motor neuron degeneration in amyotrophic lateral sclerosis.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献