Department of Dermatology and Venereology, Faculty of Health Sciences, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel -
Department of Dermatology, Sackler Faculty of Medicine, Rabin Medical Center, Tel-Aviv University, Tel-Aviv, Israel.
G Ital Dermatol Venereol. 2019 Aug;154(4):413-417. doi: 10.23736/S0392-0488.19.06157-1. Epub 2019 Feb 14.
Acute generalized exanthematous pustulosis (AGEP) is a rare pustular severe cutaneous adverse reaction. Differentiating between AGEP and pustular psoriasis may represent a diagnostic challenge. We sought to evaluate the prevalence of comorbidities in a series of patients with AGEP compared to a series of patients with psoriasis vulgaris and to a series of patients with drug-related psoriasis.
Medical records of 14 patients with AGEP, 33 patients with psoriasis vulgaris, and 18 patients with drug-related psoriasis were reviewed. The presence of comorbidities was recorded, and a comparative analysis was performed.
A personal history of psoriasis was present in 4 (28%) patients with AGEP compared to 12 (66%) patients with drug-related psoriasis (Pv=0.03). The prevalence of psoriasis-related morbidities was significantly lower in the AGEP group compared to the psoriasis group and to the drug-related psoriasis group (Pv<0.01, 0.05, respectively). Each of the psoriasis-related morbidities had significantly lower prevalence in the AGEP group compared to the psoriasis group and to the drug-related psoriasis group (Pv<0.01).
In conclusion, differences between AGEP, psoriasis vulgaris, and drug-related psoriasis regarding the prevalence of psoriasis-related morbidities may assist differentiation in borderline cases.
急性泛发性发疹性脓疱病（AGEP）是一种罕见的脓疱性严重皮肤不良反应。区分 AGEP 和脓疱性银屑病可能具有诊断挑战性。我们旨在评估一系列 AGEP 患者与一系列寻常型银屑病患者和一系列药物相关性银屑病患者的合并症患病率。
回顾了 14 例 AGEP 患者、33 例寻常型银屑病患者和 18 例药物相关性银屑病患者的病历。记录了合并症的存在，并进行了比较分析。
与药物相关性银屑病患者（66%）相比，有 4 例（28%）AGEP 患者有银屑病个人史（Pv=0.03）。与银屑病组和药物相关性银屑病组相比，AGEP 组的银屑病相关合并症患病率明显较低（Pv<0.01，Pv<0.05）。与银屑病组和药物相关性银屑病组相比，每个银屑病相关合并症在 AGEP 组的患病率均明显较低（Pv<0.01）。
总之，AGEP、寻常型银屑病和药物相关性银屑病之间在银屑病相关合并症的患病率方面的差异可能有助于区分边界病例。
