Pearson Kelly C, Morrell Dean S, Runge Susan R, Jolly Puneet
University of North Carolina, Chapel Hill, USA.
Cutis. 2016 Mar;97(3):212-6.
Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous eruption that often is a reaction to medications, most commonly antibiotics. Clinically, AGEP closely mimics pustular psoriasis and also is similar to subcorneal pustular dermatosis and IgA pemphigus. For clinicians, it is important to differentiate AGEP from pustular psoriasis. Acute generalized exanthematous pustulosis will have an acute drug association. Few cases have been known to be caused by hydroxychloroquine (HCQ). Proper therapeutic management of AGEP includes withdrawal of the offending agent, and resolution typically occurs within 15 days. We report a case of AGEP after HCQ administration that did not follow the usual course of resolution after medication cessation. The patient continued to experience cutaneous eruptions that waxed and waned for 81 days. Hydroxychloroquine has a particularly long half-life and is a known cause of AGEP; therefore, it is possible that HCQ-induced AGEP may not follow the typical rapid recovery time.
急性泛发性脓疱性皮病（AGEP）是一种罕见的皮肤疹，通常是对药物的反应，最常见的是抗生素。临床上，AGEP与脓疱型银屑病极为相似，也类似于角层下脓疱性皮肤病和IgA天疱疮。对临床医生来说，将AGEP与脓疱型银屑病区分开来很重要。急性泛发性脓疱性皮病会与药物有急性关联。已知很少有病例是由羟氯喹（HCQ）引起的。AGEP的正确治疗管理包括停用致病药物，通常在15天内消退。我们报告一例服用HCQ后发生的AGEP病例，停药后未遵循通常的消退过程。患者持续出现皮疹，反复出现达81天。羟氯喹有特别长的半衰期，是已知的AGEP病因；因此，HCQ诱发的AGEP可能不遵循典型的快速恢复时间。
