Albany Medical College, Albany, New York, NY, USA.
Department of Dermatology and Allergy, University Hospital of Basel, Basel, Switzerland.
Am J Clin Dermatol. 2023 Jul;24(4):557-575. doi: 10.1007/s40257-023-00779-3. Epub 2023 May 8.
Acute generalized exanthematous pustulosis (AGEP) is a rare, acute, severe cutaneous adverse reaction mainly attributed to drugs, although other triggers, including infections, vaccinations, ingestion of various substances, and spider bites, have also been described. AGEP is characterized by the development of edema and erythema followed by the eruption of multiple punctate, non-follicular, sterile pustules and subsequent desquamation. AGEP typically has a rapid onset and prompt resolution within a few weeks. The differential diagnoses for AGEP are broad and include infectious, inflammatory, and drug-induced etiologies. Diagnosis of AGEP depends on both clinical and histologic criteria, as cases of overlap with other disease processes have been reported. Management includes removal of the offending drug or treatment of the underlying cause, if necessary, and supportive care, as AGEP is a self-limited disease. This review aims to provide an overview and update on the epidemiology, pathogenesis, reported precipitating factors, differentials, diagnosis, and management of AGEP.
急性泛发性发疹性脓疱病（AGEP）是一种罕见的急性严重皮肤不良反应，主要归因于药物，但也有其他诱因，包括感染、疫苗接种、摄入各种物质和蜘蛛咬伤。AGEP 的特征是在出现水肿和红斑后，出现多个点状、非滤泡性、无菌脓疱，随后出现脱皮。AGEP 通常发病迅速，数周内迅速缓解。AGEP 的鉴别诊断范围广泛，包括感染性、炎症性和药物性病因。AGEP 的诊断取决于临床和组织学标准，因为已有报告称该病与其他疾病过程重叠。治疗包括去除致病药物或必要时治疗潜在病因，并给予支持性治疗，因为 AGEP 是一种自限性疾病。本综述旨在提供 AGEP 的流行病学、发病机制、已报告的诱发因素、鉴别诊断、诊断和治疗的概述和更新。
