Semmel M, Hanania N, Huet S, Pavloff N, Gay F, Biquard J M
U.A. 1158 C.N.R.S., Institut Gustave Roussy, Villejuif, France.
Mol Biol Rep. 1988;13(3):151-7. doi: 10.1007/BF00444311.
Hexamethylenbisacetamide (HMBA) can induce the Burkitt lymphoma Raji cells to enter the differentiation process as evidenced by the decrease of HLA-DR antigens. This event is preceded by a decrease of c-myc expression and of the phosphorylation of cellular proteins, due to either a decrease of tyrosine protein kinase activity or an increase of tyrosine phosphatase activity. These three events form a sequence and are part of the genetic program for differentiation and growth though they may not be causally related.
六亚甲基双乙酰胺（HMBA）可诱导伯基特淋巴瘤Raji细胞进入分化过程，这可通过HLA - DR抗原的减少得以证明。此事件之前，c - myc表达及细胞蛋白磷酸化减少，这是由于酪氨酸蛋白激酶活性降低或酪氨酸磷酸酶活性增加所致。这三个事件形成一个序列，并且是分化和生长遗传程序的一部分，尽管它们可能没有因果关系。
