多孔氧化石墨烯增强适体特异性循环肿瘤细胞传感界面在光寻址电位传感器上的临床应用和模拟。
Porous Graphene Oxide Enhanced Aptamer Specific Circulating-Tumor-Cell Sensing Interface on Light Addressable Potentiometric Sensor: Clinical Application and Simulation.
机构信息
College of Electronic Information and Optical Engineering , Nankai University , Tianjin 300071 , China.
School of Medical Laboratory , Tianjin Medical University , Tianjin 300070 , China.
出版信息
ACS Appl Mater Interfaces. 2019 Mar 6;11(9):8704-8709. doi: 10.1021/acsami.8b21101. Epub 2019 Feb 20.
The circulating-tumor-cell (CTC) specific aptamer is believed to be a power recognition factor to realize clinical CTC assay. However, the limited sensing range is still one of the challenges in its real application. The porous-graphene-oxide (PGO) enhanced aptamer specific CTC sensing interface is studied on the platform of light-addressable-potentiometric-sensor (LAPS) to provide a clinical available method for CTC detection. The underlying mechanism of this sensing interface on LAPS is modeled and simulated. It is confirmed to be a promising candidate for CTC assay by the linear responding for 5-5000 spiked cells, as well as the satisfactory sensitivity for clinical samples.
循环肿瘤细胞（CTC）特异性适体被认为是实现临床 CTC 检测的强大识别因素。然而，其在实际应用中的局限性仍是一个挑战。本研究在光寻址电位传感器（LAPS）平台上，对多孔氧化石墨烯（PGO）增强适体特异性 CTC 传感界面进行了研究，为 CTC 检测提供了一种临床可用的方法。对该传感界面在 LAPS 上的工作机制进行了建模和模拟。通过对 5-5000 个有丝分裂细胞的线性响应，以及对临床样本的令人满意的灵敏度，证实了该传感界面在 CTC 检测方面具有广阔的应用前景。
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