Sun Hongcun, Hu Jiandao, Mao Zhenyu, Ma ZhaoXin
a Department of Otolaryngology, Head and Neck Surgery , Shanghai East Hospital, Tongji University School of Medicine , Shanghai , China.
b Department of Otolaryngology, Head and Neck Surgery , Yin Zhou Hospital Affiliated to Medical School Of Ningbo University , Ningbo , China.
Acta Otolaryngol. 2019 Mar;139(3):258-262. doi: 10.1080/00016489.2018.1554266. Epub 2019 Feb 14.
Combination therapy is the first-line option for total-deafness sudden sensorineural hearing loss (SSNHL). Age may act as a crucial prognostic factor.
The aim of this study was to compare efficacy of combination therapy between adolescent and adult patients with total-deafness SSNHL.
Twenty-five adolescent patients (adolescent group) and 106 adult patients (adult group) with total-deafness SSNHL were recruited. All the recruited patients underwent initial treatment with batroxobin, methylprednisolone, and gastrodin. After 10-day treatment, hearing outcomes were determined by pure-tone average measured by audiometry. Moreover, the total effective rates in the hearing recovery and improvement of tinnitus were calculated.
There existed no significant difference between two groups in the total effective rate of the hearing recovery (p = .110). However, a significant difference was found in the total effective rate of improvement of tinnitus between two groups (p = .016). Both adolescent and adult patients could receive the optimal hearing gains at 500 Hz (20.2 ± 13.3 and 23.1 ± 13.9dB, respectively), followed by those at 1000 Hz (18.8 ± 12.5 and 22.7 ± 14.8dB, respectively). Yet, adult patients could get better hearing gains only at 500 Hz than adolescent patients (p = .02).
Compared with adult patients, adolescent patients with total-deafness SSNHL undergoing combination therapy may be less likely to have hearing recovery and the improvement of tinnitus.
联合治疗是全聋型突发性感音神经性听力损失（SSNHL）的一线治疗选择。年龄可能是一个关键的预后因素。
本研究旨在比较青少年和成年全聋型SSNHL患者联合治疗的疗效。
招募了25例青少年患者（青少年组）和106例成年全聋型SSNHL患者（成年组）。所有入选患者均接受了巴曲酶、甲泼尼龙和天麻素的初始治疗。治疗10天后，通过听力计测量的纯音平均听阈来确定听力结果。此外，计算听力恢复和耳鸣改善的总有效率。
两组听力恢复的总有效率无显著差异（p = 0.110）。然而，两组耳鸣改善的总有效率存在显著差异（p = 0.016）。青少年和成年患者在500Hz时均可获得最佳听力增益（分别为20.2±13.3dB和23.1±13.9dB），其次是在1000Hz时（分别为18.8±12.5dB和22.7±14.8dB）。然而，成年患者仅在500Hz时比青少年患者获得更好的听力增益（p = 0.02）。
与成年患者相比，接受联合治疗的全聋型SSNHL青少年患者听力恢复和耳鸣改善的可能性可能较小。
